Ming-Ming Zhou, PhD

Zhou, M.-M., & Cole, P.A. (2025) Targeting Lysine Acetylation Readers and Writers. Nature Reviews Drug Discovery, 24(2):112-133

Vann, K.R., Sharma, R., Hsu, C.-C., Devoucoux, M., Tencer, A.H., Zeng, L., Lin, K., Zhu, L., Li, Q., Lachance, C., Ospina, R.R., Tong, Q., Cheung, K.L., Yang, S., Xuan, H., Gatchalian, J., Alamillo, L., Wang, J., Jang, S.M., Klein, B.J., Lu, Y., Strahl, B.D., Rothbart, S.B., Walsh, M.J., Cleary, M.L., Côté, J., Shi, X., Zhou, M.-M.*, & Kutateladze, T.G.* (2025) Structure-Function Relationship of ASH1L and Histone H3K26 and H3K4 Methylation. Nature Commun., 16(1): 2235. PMID: 40044670.

Liu, N., Konuma, K., Sharma, R., Wang, D., Zhao, N., Cao, L.L., Ju, Y., Liu, D., Wang, Shui, Bosch, A., Sun, Y.F., Zhang, S., Ji, D.L., Nagatoishi, S., Suzuki, N., Kikuchi, M., Wakamori, M., Zhao, C.C., Ren, C.Y., Zhou, T.J.C., Xu. Y.Y., Meslamani, J., Fu, S.B., Umehara, T., Tsumoto, K., Akashi, S., Zeng, L., Roeder, R.G., Walsh, M.J., Zhang, Q., & Zhou, M.-M. (2023) Histone H3 Lysine 27 Crotonylation Mediates Gene Transcriptional Repression in Chromatin. Mol. Cell 83(13): 2206-2221.

Yu, D., Liang, Y., Kim, C., Jaganathan, A., Ji, D., Han, X., Yang, X., Jia, Y., Gu, R., Wang, C., Zhang, Q., Cheung, K.L., Zhou, M.-M., & Zeng, L. (2023) Structural Mechanism of BRD4-NUT and p300 Bipartite Interactions in Propagating Aberrant Gene Transcription in Chromatin in NUT Carcinoma. Nature Commun. 14(1): 378.

Han, X.Y., Yu, D., Gu, R.R., Jia, Y.J., Wang, Q., Yang, X.L., Yu, M.M., Babault, N., Zhao, C.C., Yi, H.F., Zhang, Q., Zhou, M.-M., & Zeng, L. (2020) Roles of BRD4 Short Isoform in Phase Separation for Active Gene Transcription. Nature Struct. & Mol. Biol., 27(4):333-341.

Shi, J., Wang, Y., Zeng, L., Wu, Y., Deng, J., Zhang, Q., Dong, C., Li, J., Rusinova, E., Zhang, G., Wang, C., Zhu, H., Evers, B.M., Zhou, M.-M., & Zhou, B.P. (2014) Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer. Cancer Cell 25(2): 210-225.

Yap, K.L., Li, S., Munoz-Cabello, A.M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, W.J., & Zhou, M.-M. (2010) Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a. Mol. Cell 38(5): 662-674.

Zeng, L., Zhang, Q., Li, S.D., Plotnikov, A.N., Walsh, M.J., & Zhou, M.-M. (2010) Mechanism and Regulation of Acetylated Histone Binding of the Tandem PHD Finger of DPF3b. Nature 466(7303): 258-62.

Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., & Zhou, M.-M. (2005) Selective Small Molecules Blocking HIV-1 Tat and Coactivator PCAF Association. Journal of Am. Chem. Soc. 127(8): 2376-2377.

Dhalluin, C., Carlson, J., Zeng, L., He, C., Aggarwal, A.K., & Zhou, M.-M. (1999) Structure and Ligand of a Histone Acetyltransferase Bromodomain. Nature 399(6735): 491-496.