Publications:126
Minghui Wang, PhD
About Me
Minghui Wang is an Associate Professor for the Department of Genetics and Genomic Sciences.
Language
English
Position
PROFESSOR | Genetics and Genomic Sciences
Research Topics
Alzheimer's Disease, Bioinformatics, Biostatistics, Cancer, Neuroscience, Parkinson's Disease
Education
PhD, Fudan University
Research
Dr Wang is working to develop integrative network models to combine large-scale matched genomic (whole-genome sequencing), transcriptomic (bulk and single cell resolution), proteomic and epigenomic (DNA methylation and ATAC-seq) data generated from diseased and control tissues, with a special focus on neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. By decoding the hidden interconnected relationships among a large network of genes/proteins that underlie the disease pathology, he aims to identify new pathways/genes/cell populations that drive the key pathways of disease, in the hope that this may lead to novel therapeutics to treat the diseases.
Publications
Selected Publications
- Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia. Swadha Singh, Marina Iskhakova, Tova Y. Lambert, Aditi Valada, Neda Shokrian, Viviana Evans, Jaroslav Bendl, Pavan K. Auluck, Stefano Marenco, Minghui Wang, Bin Zhang, Gabriel E. Hoffman, Kiran Girdhar, Panos Roussos, Schahram Akbarian. Nature Communications
- Functional implications of polygenic risk for schizophrenia in human neurons. P. J. Michael Deans, Kayla G. Retallick-Townsley, Aiqun Li, Carina Seah, Jessica Johnson, Judit Garcia Gonzalez, Evan Cao, Nadine Schrode, Alex Yu, Sam Cartwright, Georgios Voloudakis, Wen Zhang, Minghui Wang, John F. Fullard, Kiran Girdhar, Eli Stahl, Schahram Akbarian, Bin Zhang, Panos Roussos, Paul O’Reilly, Laura M. Huckins, Kristen J. Brennand. Nature Communications
- Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences. Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Meghan McReynolds, Yuzhou Chang, Fangfang Qi, William Tauer, Cassandra Rosenberg, Melissa Wren, Tadafumi C. Ikezu, Yuka A. Martens, Minghui Wang, Bin Zhang, Gregory W. Carter, Michael Sasner, David M. Holtzman, Junmin Peng, Long Jun Wu, Takahisa Kanekiyo, Chia Chen Liu, Guojun Bu. Molecular Neurodegeneration
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Below are financial relationships with industry reported by Dr. Wang during 2025 and/or 2026. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting or Other Professional Services
Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership- University of Oxford
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.