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Nadejda Tsankova, MD, PhD
Anatomic Pathology and Clinical Pathology
About Me
Dr. Tsankova is a tenured Professor in Pathology, Neuroscience, and a member of the Tisch Cancer Institute and the Friedman Brain Institute. She leads an NIH-funded laboratory in neuro-oncology, which studies the molecular mechanisms of glioma growth and invasion in the context of neurodevelopmental dysfunction, using endogenous human-based models. She is also the Director of Neuropathology
the Program Director of the Neuropathology Fellowship, and a practicing diagnostic pathologist. Dr. Tsankova received her Ph.D. from UT Southwestern Medical Center, where she trained with Dr. Eric Nestler. Under his guidance, she pioneered the studies of neuroepigenetics in the context of chronic stress/depression. Following the path of a Physician-Scientist, she completed her residency in Anatomic Pathology and fellowship in Neuropathology at Columbia University, where she became intrigued with studying the pathogenesis of human gliomas. She worked in the laboratory of Dr. Fiona Doetsch, where she developed novel techniques to isolate and characterize endogenous neural/glial progenitors from human brain, creating a transitional, human-based system to study epigenetic dysregulation during gliomagenesis. During her career, as faculty first at Columbia University and since 2014 at Mount Sinai, Dr. Tsankova has developed fruitful and ongoing collaborations with several investigators from the departments of Neurosurgery, Neuroscience, and Psychiatry.
Visit Dr. Tsankova's lab page at: http://labs.icahn.mssm.edu/tsankovalab/
Language
English
Position
PROFESSOR | Pathology, Molecular and Cell Based Medicine, PROFESSOR | Neuroscience
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Anti-Tumor Therapy, Brain, Cancer Genetics, Cell Transformation, Chromatin, Stem Cells
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
Education
MD, University of Texas Southwestern Medical School
PhD, University of Texas - Southwestern Medical Center
Residency, Pathology, Neuropathology
Columbia University Irving Medical Center
Fellowship, Neuropathology
Columbia University Irving Medical Center
Certifications
American Board of Pathology
Awards
2022
Permanent member, NIH Clinical Neuroimmunology and Brain Tumor Study Section
NIH
2021
Rubenstein Award
AANP
2016
Faculty Idea Prize Winner, Mount Sinai Innovations
Mount Sinai Hospital
2016
Friedman Brain Institute Research Scholar
Mount Sinai Hospital
2013
Clinical Trials Office Research Pilot Award
Irving Institute
2008
Stembridge Award for Excellence in Pathology
University of Texas
2000
Medical Scientist Training Program Fellowship
1998
Howard Hughes Fellowship for summer research
1998
Presidential Endowed Scholarship
Research
The main research focus of the Tsankova laboratory is to understand the cellular and molecular mechanisms driving aberrant glial proliferation and migration in two debilitating CNS disorders – glioblastoma and epilepsy, focusing on the role of epigenetics and the transcriptional machinery in maintaining these dysfunctional glial phenotypes. Our primary model is human pathological tissue obtained from neurosurgical resections and perpetuated in the form of spheroids or mouse xenografts. Our lab has developed unique techniques for the acute isolation of viable glial/neural populations in such tissues, using novel markers for cell quiescence and activation. The lab is actively characterizing, both functionally and molecularly, novel populations of cancer stem cells and pathologically remodeled glial progenitors, in order to obtain deeper mechanistic insight into the role of glial proliferation and migration in CNS disease as well as to discover superior new targets for treatment of glioblastoma and drug-resistant epilepsy. We are using various techniques, such as ChIP-seq, ATAC-seq, single cell and bulk RNA-seq, CRISPR/Cas9 genome editing, tissue culture, and orthotopic xenotransplantation, and collaborate with several labs who share our passion for neuro-epigenetics.
Insurance Information
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Publications
Selected Publications
- LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment. Yonger Xue, Xucheng Hou, Yichen Zhong, Yuebao Zhang, Shi Du, Diana D. Kang, Leiming Wang, Chang Wang, Haoyuan Li, Siyu Wang, Zhengwei Liu, Meng Tian, Kaiyuan Guo, Dinglingge Cao, Binbin Deng, David W. McComb, Eric Purisic, Jinye Dai, Pauline Hamon, Brian D. Brown, Nadejda M. Tsankova, Miriam Merad, Darrell J. Irvine, Ron Weiss, Yizhou Dong. Nature Communications
- Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches. Sangjo Kang, Mary E. Ughetta, Jack Y. Zhang, Valerie J. Marallano, Anirudh Sattiraju, Theodore Hannah, Shalaka Wahane, Aarthi Ramakrishnan, Molly Estill, Nadejda M. Tsankova, Li Shen, Alexander M. Tsankov, Roland H. Friedel, Hongyan Zou. Nature Cancer
- Single chromatin fiber profiling and nucleosome position mapping in the human brain. Cyril J. Peter, Aman Agarwal, Risa Watanabe, Bibi S. Kassim, Xuedi Wang, Tova Y. Lambert, Behnam Javidfar, Viviana Evans, Travis Dawson, Maya Fridrikh, Kiran Girdhar, Panos Roussos, Sathiji K. Nageshwaran, Nadejda M. Tsankova, Robert P. Sebra, Mitchell R. Vollger, Andrew B. Stergachis, Dan Hasson, Schahram Akbarian. Cell Reports Methods
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Tsankova has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.