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Profile image of Nan Yang

    Nan Yang, PhD

    Education

    Exchange student, University of California, San Francisco

    PhD, Fundan University

    Postdoctoral, Stanford University

    Awards

    2014

    NARSAD Young Investigator

    Research

    Advances in human genetics and next-generation sequencing have permitted the identification of a stunning number of genetic variants that are linked to autism spectrum disorder (ASD), providing a platform for unraveling the causal chain of events that result in the disorder. However, the availability of data is not synonymous with the presence of meaning. Indeed, the challenge researchers are facing now is the derivation of biological meaning post-GWAS. Particularly, an increasing number of risk-associated variants are found in non-coding sequences. We use stem cell modeling system, genome engineering, CRISPR-mediated epigenetic editing, and state-of-the-art single-cell sequencing technology to determine the molecular impact of such non-coding sequence alterations.