Paul J Kenny, PhD

The Kenny Laboratory is driven by a central goal: to unravel the brain mechanisms that underlie addiction, obesity, and schizophrenia. We are particularly interested in how distributed brain networks shape motivation, decision-making, and vulnerability to neuropsychiatric illness. Our research integrates a multidisciplinary and technology-forward approach. We use sophisticated behavioral paradigms, including artificial intelligence–driven platforms that enable high-throughput quantification of behavior. These analyses are complemented by modern molecular tools, such as viral vector-mediated gene transfer and CRISPR-based genome editing, which allow us to manipulate and monitor specific genes and neural circuits in vivo. To gain insight into the cellular architectures underlying brain disorders, we employ next-generation sequencing technologies, including single-cell and spatial transcriptomics, to map gene expression and cell states across diverse brain regions. In parallel, we utilize unbiased whole-brain activity mapping strategies, such as cFos-based whole-brain imaging and tissue clearing techniques, to identify the neural networks engaged by drugs of abuse and other neuropsychiatric stressors. By combining systems-level discovery with mechanistic precision, our work aims to reveal novel therapeutic targets for treating some of the most complex and debilitating brain disorders. The lab offers a dynamic and collaborative environment for highly motivated graduate students and postdoctoral fellows to explore big questions using cutting-edge tools in neuroscience. 
Search PubMed for articles