Publications:130
Paul Slesinger, PhD
About Me
Paul Slesinger PhD is Lillian and Henry M. Stratton Professor of Neuroscience and Director of the Center for Neurotechnology and Behavior. Our long-term objective is to discover new drugs for treating addiction to drugs of abuse and alcohol. We focus on changes in neuronal excitability with drugs, and take a broad approach of combining structural biology, biochemistry, electrophysiology and behavior. Visit Paul Slesinger's Laboratory of Membrane Excitability & Disease for more details.
Language
English
Position
PROFESSOR | Graduate Education, PROFESSOR | Neuroscience, PROFESSOR | Pharmacological Sciences, VICE CHAIR FOR NASH DEPARTMENT OF NEUROSCIENCE | Neuroscience
Research Topics
Addiction, Biophysics, Electrophysiology, Neurophysiology, Neuroscience, Protein Trafficking & Sorting, Signal Transduction, Synaptic Plasticity
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
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BA, Reed College
PhD, University of California, San Francisco
Postdoctoral Fellow, University of California, San Francisco
Awards
2006
NARSAD Independent Investigator Award
2003
McKnight Technological Innovations in Neuroscience Award
2001
Human Frontiers Science Program Young Investigator Grant
1999
McKnight Scholars Award in Neuroscience
1998
Alfred P. Sloan Research Fellow
Research
Project: We are developing tools for measuring the real-time release of neuropeptides in freely behaving animals using new biosensors (i.e., CNiFERs) and custom-made Miniscopes.
Project: We are developing nanovesicles engineered for photorelease of drugs in vivo in real-time.
Publications
Selected Publications
- Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons. Isabel Gameiro-Ros, Adam J. Tengolics, Iya Prytkova, Chella Kamarajan, Zhiping P. Pang, Alison M. Goate, Ronald P. Hart, Paul A. Slesinger. iScience
- A critical residue mediates proper assembly and gating of GIRK2 channels. Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger. Journal of General Physiology
- Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. Nicholas C. Green, Hongyu Gao, Xiaona Chu, Qiuyue Yuan, Patrick McGuire, Dongbing Lai, Guanglong Jiang, Xiaoling Xuei, Jill L. Reiter, Julia Stevens, Greg T. Sutherland, Alison M. Goate, Zhiping P. Pang, Paul A. Slesinger, Ronald P. Hart, Jay A. Tischfield, Arpana Agrawal, Yue Wang, Zhana Duren, Howard J. Edenberg, Yunlong Liu. Nature Communications
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Slesinger has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.