Publications:128
Paul Slesinger, PhD
About Me
Paul Slesinger PhD is Lillian and Henry M. Stratton Professor of Neuroscience and Director of the Center for Neurotechnology and Behavior. Our long-term objective is to discover new drugs for treating addiction to drugs of abuse and alcohol. We focus on changes in neuronal excitability with drugs, and take a broad approach of combining structural biology, biochemistry, electrophysiology and behavior. Visit Paul Slesinger's Laboratory of Membrane Excitability & Disease for more details.
Language
English
Position
PROFESSOR | Neuroscience, PROFESSOR | Pharmacological Sciences, VICE CHAIR FOR NASH DEPARTMENT OF NEUROSCIENCE | Neuroscience
Research Topics
Addiction, Biophysics, Electrophysiology, Neurophysiology, Neuroscience, Protein Trafficking & Sorting, Signal Transduction, Synaptic Plasticity
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
Download the CVEducation
BA, Reed College
PhD, University of California, San Francisco
Postdoctoral Fellow, University of California, San Francisco
Awards
2006
NARSAD Independent Investigator Award
2003
McKnight Technological Innovations in Neuroscience Award
2001
Human Frontiers Science Program Young Investigator Grant
1999
McKnight Scholars Award in Neuroscience
1998
Alfred P. Sloan Research Fellow
Research
Project: Investigating the structural and molecular determinants of GIRK channel gating and modulation. Project: Investigating the neuronal activity and neurotransmitter release in the reward circuitry during alcohol intake, using fiber photometry to measure fluorescence in freely moving animals that express genetically encoded calcium and neurotransmitter indicators. Project: Investigating the physiological roles of the GIRK channels in the brain disorders, and developing pharmacological tools to modulate GIRK channels in these disorders.
Publications
Selected Publications
- A critical residue mediates proper assembly and gating of GIRK2 channels. Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger. Journal of General Physiology
- Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. Nicholas C. Green, Hongyu Gao, Xiaona Chu, Qiuyue Yuan, Patrick McGuire, Dongbing Lai, Guanglong Jiang, Xiaoling Xuei, Jill L. Reiter, Julia Stevens, Greg T. Sutherland, Alison M. Goate, Zhiping P. Pang, Paul A. Slesinger, Ronald P. Hart, Jay A. Tischfield, Arpana Agrawal, Yue Wang, Zhana Duren, Howard J. Edenberg, Yunlong Liu. Nature Communications
- Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2. Chrystian Junqueira Alves, Theodore Hannah, Sita Sadia, Christy Kolsteeg, Angela Dixon, Robert J. Wiener, Ha Nguyen, Murray J. Tipping, Júlia Silva Ladeira, Paula Fernandes da Costa Franklin, Nathália de Paula Dutra de Nigro, Rodrigo Alves Dias, Priscila V. Zabala Capriles, José P. Rodrigues Furtado de Mendonça, Paul A. Slesinger, Kevin D. Costa, Hongyan Zou, Roland H. Friedel. Nature Communications