Publications:139
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Allergy and Immunology
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About Me
Paula J. Busse MD is a Professor in the Department of Medicine, Division of Clinical Immunology. She received her undergraduate education at Wellesley College and her medical degree from the University of Rochester. She completed her medical residency training in Internal Medicine and her post-doctorate training in Allergy and Immunology at the Mount Sinai School of Medicine, where she also completed a graduate clinical research training program. Her clinical and research areas of interest are asthma in older patients and treatment of hereditary angioedema. Dr. Busse is funded by the National Institutes of Health and several foundation grants. She is active in the American Academy of Allergy, Asthma and Immunology, giving lectures at national and local meetings and is involved in several of its committees. She has been elected to the Hereditary Angioedema Association Scientific Medical Advisory Board. She has been a small group discussion leader for the first-year medical student basic immunology course for several years.
Language
Position
Hospital Affiliations
- Mount Sinai Morningside
- Mount Sinai Beth Israel
- Mount Sinai Brooklyn
- Mount Sinai Queens
- The Mount Sinai Hospital
- Mount Sinai West
About Me
Paula J. Busse MD is a Professor in the Department of Medicine, Division of Clinical Immunology. She received her undergraduate education at Wellesley College and her medical degree from the University of Rochester. She completed her medical residency training in Internal Medicine and her post-doctorate training in Allergy and Immunology at the Mount Sinai School of Medicine, where she also completed a graduate clinical research training program. Her clinical and research areas of interest are asthma in older patients and treatment of hereditary angioedema. Dr. Busse is funded by the National Institutes of Health and several foundation grants. She is active in the American Academy of Allergy, Asthma and Immunology, giving lectures at national and local meetings and is involved in several of its committees. She has been elected to the Hereditary Angioedema Association Scientific Medical Advisory Board. She has been a small group discussion leader for the first-year medical student basic immunology course for several years.
Language
Position
Hospital Affiliations
- Mount Sinai Morningside
- Mount Sinai Beth Israel
- Mount Sinai Brooklyn
- Mount Sinai Queens
- The Mount Sinai Hospital
- Mount Sinai West
Clinical Focus
- Allergic Asthma
- Allergic Contact Dermatitis
- Allergic Cough
- Allergic Rhinitis
- Allergy Injections
- Allergy Testing
- Anaphylaxis
- Angioedema
- Asthma
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Education
MD, University of Rochester School of Medicine/Dentistry
Residency, Internal Medicine
Mount Sinai Hospital
Fellowship, Allergy & Immunology
Mount Sinai Hospital
Certifications
American Board of Allergy & Immunology
American Board of Internal Medicine
Awards
2008
Allergy, Asthma and Immunology Education and Research Trust/Journal of Clinical Immunology Research Award
2003
Dr. Solomon Silver Award
Clinical Medicine (MSH)
2003
T. Franklin Williams Scholar Award
2002
ACAAI Young Faculty Award
New award
Research
Asthma in older patients
Asthma morbidity and mortality is highest in patients >65 years old, and underlying airway inflammation in this age group has not been characterized. In this laboratory, we have studied a model of asthma in aged mice and have investigated whether age alters modulation of airway inflammation. Presently, the laboratory is translating these studies to evaluate clinical characteristics of asthma in older patients and markers of inflammation in the airways of these patients. This knowledge will help to direct age-specific anti-inflammatory asthma therapy.
Hereditary Angioedema (HAE)
HAE is a rare disease which affects approximately 4,000 people in the US. Its symptoms include swelling of the face, airway, extremities and abdomen. If swelling involves the airways, it can be life-threatening. Our group has been involved in several clinical trials for new medications to treat HAE. In addition, the laboratory is presently studying mechanisms by whichestrogen can exacerbate HAE.
Selected publications
Zuraw BL, Banerji A, Bernstein JA, Busse PJ, Christiansn SC, Davis-Lorton M, Frank MM, Li HH, Lumry WR, Riedl M. US Hereditary Angioedema Association Medical Advisory Board 2013 Recommendation for the management of Hereditary Angioedema due to C1 Inhibitor deficiency. J Allergy and Clin Immunol: In Practice 2013; 1 (6): 458-467.
Birmingham JM, Patil S, Li XM, Busse PJ. The effect of oral tolerance on the allergic airway response in young and aged mice. J Asthma 2013: 50 (2): 122-32.
Busse PJ, Cohn RD, Salo PM, Zeldin DL. Characteristics of allergic sensitization among adult asthmatics >55 years: Results from the National Health and Nutrition Examination Survey 2005-2006. Ann Allergy Asthma Immunol 2013; 110 (4) 247-52.
Riedl MA, Hurewitz DS, Levy R, Busse PJ, Fitts D, Kalfus I. Nanofiltered C1 esterase inhibitor (human) for the treatment of acute attacks of hereditary angioedema: an open-label trial. Ann Allergy Asthma Immunol 2012; 108: 49-53.
Busse PJ, Lurshurchadia L, Sampson H, Halm EA, Wisnivesky J. Perennial allergen-specific immunoglobulin E levels among inner-city elderly asthmatics. J Asthma 2010; 47 (7): 781-5.
Zuraw BL, Busse PJ, White M, et al. Nanofiltered C1 Inhibitor Concentrate for treatment of hereditary angioedema. NEJM 2010; 363 (6): 513-22.
Busse PJ, Schofield B, Birmingham N, Yang N, Wen MC, Zhang T, Srivastava K, Li XM. The traditional Chinese Herbal Formula, ASHMI, inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice. Ann Allergy Asthma Immunol 2010; 104 (3): 236-246.
Busse PJ, Zhang TF, Schofield B, Kilaru K, Patil S, Li XM. Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma. Ann Allergy Asthma Immunol 2009; 103 (4): 295-303.
Busse PJ, Zhang, TF, Srivastava K, Schofield B, Li XM. Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice. Clin Exp Allergy 2007; 37 (9): 1392-1403.
Clinical trials
Anti IL-5 (Mepolizumab) treatment in hypereosinophilic syndrome
Consulting
CSL Behring, Viropharma/Shire, Dyax Corp, Gerson Lehrman Group
Locations
Insurance Information
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- Department of Medicine - Allergy & Immunology5 East 98th Street, 11th Floor, New York, NY, 10029
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Publications
Selected Publications
- Effective long-term prophylaxis with lanadelumab in adolescents with hereditary angioedema: EMPOWER/ENABLE. Raffi Tachdjian, Aleena Banerji, Paula J. Busse, Nancy Agmon-Levin, John Anderson, Mauro Cancian, Giuseppe Spadaro, Carmen Enciu, Daniel Nova Estepan, Natalie Khutoryansky, Siddharth Jain, Andreas Recke. Pediatric Allergy and Immunology
- The relationship between depressive symptoms and coping style on asthma outcomes in older adults. Naomi Greenfield, Matthew Wysocki, Kimberly Arcoleo, Juliana Rodriguez, Sunit Jariwala, Paula Busse, Alex Federman, Juan Wisnivesky, Jonathan M. Feldman. Journal of Behavioral Medicine
- Asthma beliefs and overuse of short-acting beta-adrenergic receptor agonists among older adults. Yoshiko Ishisaka, Jyoti Ankam, Jonathan Feldman, Paula Busse, Juan P. Wisnivesky, Alex D. Federman. Journal of Asthma
Patient Experience Star Ratings and Comments
The Patient Experience Star Rating reflects our patients’ perception of how well their Mount Sinai provider communicated with them during an office visit. The Star Rating is based on patient responses to three questions on a patient experience survey, a standardized questionnaire sent to verified patients and distributed by a third party vendor, Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Below are financial relationships with industry reported by Dr. Busse during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
- CVS Health
- Takeda
- CSL Behring
- Pharvaris
- BioCryst Pharmaceuticals, Inc.
- Kalvista
- Intellia Therapeutics, Inc.
- Ionis Pharmaceuticals
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Below are financial relationships with industry reported by Dr. Busse during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
- CVS Health
- Takeda
- CSL Behring
- Pharvaris
- BioCryst Pharmaceuticals, Inc.
- Kalvista
- Intellia Therapeutics, Inc.
- Ionis Pharmaceuticals
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.