Disease Mechanisms and Therapeutics (DMT), Microbiology [MIC]
Video
Education
PhD, University of Vienna
Awards
2015
Beijerinck Virology Prize
Royal Netherlands Academy of Arts and Sciences
2014
Elected Fellow of the American Academy of Arts and Sciences
2014
Honorary Doctorate
Baylor College of Medicine
2012
Sanofi–Institut Pasteur Award
2012
Election to the Institute of Medicine of the National Academy of Sciences
2010
European Virology Award (EVA)
European Society for Virology
2006
Elected Member
The German Academy of Sciences Leopoldina
2006
Robert Koch Prize
Berlin
2002
Corresponding Member
Austrian Academy of Sciences
2000
Member
National Academy of Sciences
Research
The Palese Laboratory focuses on fundamental questions concerning the genetic make-up and biology of viruses, as well as virus-host interactions. They use molecular biological techniques to understand how viruses replicate and how they interact with cells to cause disease in their hosts. Emphasis is on the study of RNA viruses, including influenza, paramyxo, and corona viruses. These are four major research directions in the laboratory at the present time: (1) by genetically changing influenza viruses via recombinant DNA techniques, they are studying viral genes and gene products to develop a universal influenza virus vaccine; (2) intracellular proteins are identified that interact with viral proteins, and the biological functions of these cellular proteins are studies; (3) attempts are made to develop broad spectrum antivirals and to identify their mechanisms of actions.
The Palese Laboratory is interested in training students and postdoctoral fellows who will become independent investigators in "molecular" studies of infectious viral diseases.