Endowed Chair, The Dr. David and Dorothy Merksamer Professor of Medicine (Allergy and Immunology)
Dr. Miller is board certified in Pulmonary Disease and Allergy and Immunology and a Fellow at the American Academy of Allergy Asthma and Immunology. She joined the faculty at Mount Sinai after a long tenure at Columbia where she served as Director of the Allergy and Immunology Fellowship program, Director of Adult Allergy, and Director of the Division of Pediatric Allergy, Immunology and Rheumatology. At Mount Sinai, she is the Chief of the Division of Clinical Immunology and Merksamer Professor in Immunology and continues her work as the Deputy Editor of The Journal of Allergy and Clinical Immunology.
Her research concentrates on the mechanisms for the onset of asthma. One large research focus involves establishing and studying a birth cohort from Northern Manhattan (Columbia Center for Children’s Environmental Health), determining the importance of environmental allergens, traffic-related pollutants, and phthalate and bisphenol A exposure to the onset of allergies, asthma, and allergic immune responses. A major emphasis is on the role of prenatal and early postnatal exposure on later pediatric and adolescent asthma risk. Additional areas of research include identifying novel genetic by environment interactions important to the onset of asthma. She also has established several mouse models examining the importance of prenatal and postnatal environmental exposures on risk for asthma and other complex diseases. More recent initiatives have been to build a program in environmental epigenetics and asthma by studying DNA methylation in cell, mouse and human systems for which she is now internationally recognized. At Sinai, she is leading efforts to build a new registry of patients undergoing immune modulation and assessing immunological signals that may correlate with disease activity and remission.
Language
English
Position
PROFESSOR | Medicine, Clinical Immunology, PROFESSOR | Environmental Medicine and Climate Science, PROFESSOR | Immunology & Immunotherapy
Hospital Affiliations
Mount Sinai Morningside
Mount Sinai Beth Israel
Mount Sinai Brooklyn
Mount Sinai Queens
The Mount Sinai Hospital
New York Eye and Ear Infirmary of Mount Sinai
Mount Sinai West
Research Topics
Allergy, Environmental Health, Epigenetics
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About Me
Endowed Chair, The Dr. David and Dorothy Merksamer Professor of Medicine (Allergy and Immunology)
Dr. Miller is board certified in Pulmonary Disease and Allergy and Immunology and a Fellow at the American Academy of Allergy Asthma and Immunology. She joined the faculty at Mount Sinai after a long tenure at Columbia where she served as Director of the Allergy and Immunology Fellowship program, Director of Adult Allergy, and Director of the Division of Pediatric Allergy, Immunology and Rheumatology. At Mount Sinai, she is the Chief of the Division of Clinical Immunology and Merksamer Professor in Immunology and continues her work as the Deputy Editor of The Journal of Allergy and Clinical Immunology.
Her research concentrates on the mechanisms for the onset of asthma. One large research focus involves establishing and studying a birth cohort from Northern Manhattan (Columbia Center for Children’s Environmental Health), determining the importance of environmental allergens, traffic-related pollutants, and phthalate and bisphenol A exposure to the onset of allergies, asthma, and allergic immune responses. A major emphasis is on the role of prenatal and early postnatal exposure on later pediatric and adolescent asthma risk. Additional areas of research include identifying novel genetic by environment interactions important to the onset of asthma. She also has established several mouse models examining the importance of prenatal and postnatal environmental exposures on risk for asthma and other complex diseases. More recent initiatives have been to build a program in environmental epigenetics and asthma by studying DNA methylation in cell, mouse and human systems for which she is now internationally recognized. At Sinai, she is leading efforts to build a new registry of patients undergoing immune modulation and assessing immunological signals that may correlate with disease activity and remission.
Language
English
Position
PROFESSOR | Medicine, Clinical Immunology, PROFESSOR | Environmental Medicine and Climate Science, PROFESSOR | Immunology & Immunotherapy
I. Leonard Bernstein, MD FAAAAI Memorial Lectureship at the AAAAI/ACAAI Joint Congress
2018
AAAAI Foundation and Sheldon L. Spector, MD FAAAAI Memorial Lectureship at the AAAAI/ACAAI Joint Congress for delivering the talk “Epigenetic Changes Ascribed to Pollutant Exposures”
2017
Thomas A. Neff Lecturer at the Thomas L. Petty Aspen Lung Conference, 60th Annual Meeting,
2015
Samberg Scholar in Children’s Health
1999
Florence and Herbert Irving Clinical Research Career Award
1990
Eve Flechner Award in Internal Medicine
Research
We are interrogating novel biomarkers that capture responses to multiple environmental stressors, and are highly sensitive to the dynamics of dysregulation, on lung function and airway inflammation. Mitochondrial (mt) DNA lacks protective histones and possesses diminished DNA repair mechanisms, rendering it more susceptible than the nuclear genome to damage by reactive oxygen species (ROS), interrupting redox homeostasis, and causing inflammation. Our group and others have shown that exposure to air pollution and allergens increases intracellular levels of ROS in mitochondria. The ensuing mtDNA damage increases its quantity or content. Urban exposures also may alter methylation at key mitochondrial replication and transcriptional control regions. Asthmatics may be more susceptible. Mitochondrial DNA damage can reverse, possibly more readily than other plasma biomarkers of oxidative stress. Our objective is to elucidate the dynamic interplay between reductions in multiple inflammatory urban exposures, attributable changes in mtDNA content and methylation, and improvements in pediatric asthma outcomes over time. We intend to capture the pivotal role of novel mt biomarkers in measuring the dynamic biological responses following induction and remediation of oxidative damage, triggered by a child's changing personal environment. Results could direct more effective personalized biomarker-guided therapy or intervention, including environmental remediation, pathway inhibitors, or dietary interventions, for children with persistent asthma, and for all children exposed to an urban environment.
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Patient Experience Rating ?
The Patient Experience Star Rating reflects our patients’ perception of how well their Mount Sinai provider communicated with them during an office visit. The Star Rating is based on patient responses to three questions on a patient experience survey, a standardized questionnaire sent to verified patients and distributed by a third party vendor, Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score.
Care Provider’s Explanation
4.8 out of 5
Care Provider’s Concern
4.6 out of 5
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4.4 out of 5
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Miller has not yet completed reporting of Industry relationships.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Miller has not yet completed reporting of Industry relationships.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.