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Robert S Krauss, PhD
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About Me
Endowed Chair, Mount Sinai Professor in Cell Biology
For more information, please visit the Krauss Laboratory website.
Language
Position
Research Topics
Cell Adhesion, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Developmental Neurobiology, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Muscle Cells, Muscular Dystrophy, Protein Kinases, Signal Transduction, Stem Cells
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]
Download the CVAbout Me
Endowed Chair, Mount Sinai Professor in Cell Biology
For more information, please visit the Krauss Laboratory website.
Language
Position
Research Topics
Cell Adhesion, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Developmental Neurobiology, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Muscle Cells, Muscular Dystrophy, Protein Kinases, Signal Transduction, Stem Cells
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]
Download the CVAbout Me
Endowed Chair, Mount Sinai Professor in Cell Biology
For more information, please visit the Krauss Laboratory website.
Language
Position
Research Topics
Cell Adhesion, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Developmental Neurobiology, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Muscle Cells, Muscular Dystrophy, Protein Kinases, Signal Transduction, Stem Cells
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]
Download the CVEducation
PhD, University of North Carolina
Postdoc, Columbia University
Awards
2010
Editorial Board
Skeletal Muscle
2006
President
Society for Muscle Biology
2006
Editorial Board
Molecular and Cellular Biology
2004
Editorial Board
Journal of Cell Science
1999
Established Investigator Award
American Heart Association
1996
Career Scientist Award
Irma T. Hirschl Trust
Research
The Krauss lab is interested in regulation of cell adhesion and signal transduction pathways during embryonic development and tissue regeneration, and how such processes may go awry in disease. The lab has two major areas of focus.
First, we are interested in development and regeneration of skeletal muscle. We have identified multiprotein cell surface complexes that promote differentiation of skeletal muscle precursor cells in response to cell-cell contact and adhesion. We use a combination of approaches, including mouse genetics, cell biology and biochemistry to probe the biological functions and molecular mechanisms of such complexes in skeletal myogenesis. We have recently turned our attention to how specific cell adhesion molecules regulate the niche and activity of muscle stem cells during homeostasis and regeneration following injury.
We are also interested mechanisms whereby the Hedgehog signaling pathway regulates development of the midline of the forebrain and midface. Mutations in Hedgehog pathway genes are associated with the common and often devastating developmental defect holoprosencephaly (HPE). However, the clinical outcome of mutation carriers is extremely variable, and additional genetic or environmental factors are required for strong defects. Using mouse models of such interactions and functional analyses of human HPE-associated mutations, we aim to provide information on mechanisms of HPE that will be valuable for genetic counseling and preventive action.
For more information, please visit the Krauss Laboratory website.
Locations
Publications
Recent Artifacts
- Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche
- Materialism meets transcendence
- CDON contributes to Hedgehog-dependent patterning and growth of the developing limb
- Gene-environment interactions in birth defect etiology: Challenges and opportunities
- The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation
- An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling
- Concepts in Multifactorial Etiology of Developmental Disorders: Gene-Gene and Gene-Environment Interactions in Holoprosencephaly
- Cell–cell contact and signaling in the muscle stem cell niche
- Δ9-tetrahydrocannabinol inhibits Hedgehog-dependent patterning during development
- Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle