Robert S Krauss

Robert S Krauss, PhD

About Me

Endowed Chair, Mount Sinai Professor in Cell Biology

Professor, Department of Cell, Developmental, and Regenerative Biology

Professor, Department of Oncological Sciences

Member, Institute for Regenerative Medicine and Black Family Stem Cell Institute

Member, Mindich Child Health and Development Institute

Member, Tisch Cancer Institute

 

For more information, please visit the Krauss Laboratory website.

Language
English
Position
PROFESSOR | Cell, Developmental & Regenerative Biology, PROFESSOR | Oncological Sciences
Research Topics

Cell Adhesion, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Developmental Neurobiology, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Muscle Cells, Muscular Dystrophy, Protein Kinases, Signal Transduction, Stem Cells

Multi-Disciplinary Training Areas

Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]

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Education

PhD, University of North Carolina
Postdoc, Columbia University

Awards

2010

Editorial Board

Skeletal Muscle

2006

President

Society for Muscle Biology

2006

Editorial Board

Molecular and Cellular Biology

2004

Editorial Board

Journal of Cell Science

1999

Established Investigator Award

American Heart Association

1996

Career Scientist Award

Irma T. Hirschl Trust

Research

The Krauss lab is interested in regulation of cell adhesion and signal transduction pathways during embryonic development and tissue regeneration, and how such processes may go awry in disease. The lab has two major areas of focus.

 

First, we are interested in development and regeneration of skeletal muscle. We have identified multiprotein cell surface complexes that promote differentiation of skeletal muscle precursor cells in response to cell-cell contact and adhesion. We use a combination of approaches, including mouse genetics, cell biology and biochemistry to probe the biological functions and molecular mechanisms of such complexes in skeletal myogenesis. We have recently turned our attention to how specific cell adhesion molecules regulate the niche and activity of muscle stem cells during homeostasis and regeneration following injury.

 

We are also interested mechanisms whereby the Hedgehog signaling pathway regulates development of the midline of the forebrain and midface. Mutations in Hedgehog pathway genes are associated with the common and often devastating developmental defect holoprosencephaly (HPE). However, the clinical outcome of mutation carriers is extremely variable, and additional genetic or environmental factors are required for strong defects. Using mouse models of such interactions and functional analyses of human HPE-associated mutations, we aim to provide information on mechanisms of HPE that will be valuable for genetic counseling and preventive action.

 

For more information, please visit the Krauss Laboratory website.

Locations

Publications

Publications:100
Selected Publications