Roman Osman | Mount Sinai

About Me

Language

English

Position

PROFESSOR | Pharmacological Sciences

Research Topics

Antigen Presentation, Apoptosis/Cell Death, Autoimmunity, Biophysics, Cancer, Computational Biology, Computer Simulation, DNA Repair, Diabetes, Drug Design and Discovery, Enzymology, Gene Regulation, Mathematical and Computational Biology, Membrane Proteins/Channels, Post-Transcriptional Processing, Proteases, Protein Complexes, Protein Folding, Protein Structure/Function, Receptors, Signal Transduction, Structural Biology, T Cells, Theoretical Biophysics, Thermodynamics, Thyroid

Multi-Disciplinary Training Areas

Artificial Intelligence and Emerging Technologies in Medicine [AIET], Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)

Education

BS, Hebrew University

MS, Graduate School of the Hebrew University

PhD, Graduate School of Tel-Aviv University

, Vanderbilt University

Research

We have developed a theoretical and computational approach to evaluate energetics and dynamics of waters trapped inside proteins. With a visiting student from the University of Barcelona, Jose Carlos Gomez, and Leonardo Pardo we have defined the properties of the network of waters in GPCRs and their ability to allosterically transfer information between two isolated binding pockets in the extra- and intracellular sites. The thermodynamic signature of these waters is of major importance in the regulation of binding and the dynamic properties of the H-bond network are important in modulating biological function. We are applying these theoretical approaches to study the role of waters in GPCR activation, protein-protein interaction and protein-small molecule complexes.