Saghi Ghaffari | Mount Sinai

About Me

Saghi Ghaffari MD-PhD is a Professor in Cell, Developmental and Regenerative Biology and a member of Black Family Stem Cell Institute and Tisch Cancer Institute. Dr. Ghaffari is a stem cell biologist with expertise in blood and blood disorders. She was trained in medicine and obtained her medical degree (Doctorat D'Etat) in Paris, France, before completing her PhD in Vancouver, Canada. She was a clinical scientist at the Whitehead Institute for Biomedical Research at MIT in Cambridge, MA, after which she joined the faculty of the Icahn School of Medicine at Mount Sinai.

To learn more visit the lab here https://labs.icahn.mssm.edu/ghaffarilab

Language

English

Position

PROFESSOR | Cell, Developmental & Regenerative Biology, PROFESSOR | Oncological Sciences

Research Topics

Blood, Cancer, Cell Transformation, Hematopoiesis, Leukemia, Metabolism, Oxidative Stress, Stem Cells

Multi-Disciplinary Training Areas

Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]

Education

MD, Universite de Paris XII, Paris, France

Clinical Scientist, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology

MSc, Universite de Paris XII, Paris, France

PhD, University of British Columbia, Vancouver, B.C., Canada

Awards

2015

American Society of Hematology Bridge Grant Award

American Society of Hematology

2011

Myeloproliferative Neoplam (MPN) Foundation

Research Foundation New Investigator Award

2008

Roche Foundation for Anemia Research (RoFAR) Award

2008

Irma Hirschl/Weill-Caulier Trust Research Award

1998

NIH Clinician Scientist Career Award

National Cancer Institute

1998

American Cancer Society Research Scholar

American Cancer Society

1991

Terry Fox Physician-Scientist Fellowship National Cancer Institute of Canada

Research

The Ghaffari lab works on exposing mechanisms that maintain healthy blood stem and progenitor cell production throughout life that may be perturbed in blood disorders. The lab explores these mechanisms to ultimately improve blood production for therapy including bone marrow transplantation and to interfere with disease. The topics of interest in the laboratory are blood forming (hematopoietic) stem cells, their alterations with aging and in myeloid malignancies as well as maturation of red blood cells and their alterations in disease. We are particularly focused on metabolic programs regulated through organelles outside of the nucleus that impact blood production. This approach has been fruitful in identifying new players that are promising in their potential impact on bone marrow transplantation. In carrying our work forward, we have set up multiple collaborations with investigators at Mount Sinai and elsewhere. Several projects derived from our work are available to PhD and MD/PhD students at Mount Sinai.