Sai Ma, PhD

Dr. Sai Ma is an Assistant Professor of Genetics and Genomic Sciences, a member of Icahn Genomics Institute, and an affiliate member of the New York Genome Center (NYGC). He received his postdoctoral training from Aviv Regev and Jason Buenrostro at Broad Institute and Harvard Department of Stem Cell and Regenerative Biology (HSCRB). His laboratory primarily focuses on innovating experimental and computational tools to investigate epigenetic mechanisms of gene regulation in single-cells across dynamic cell fate transitions. The importance of his work is in helping to understand the molecular mechanisms and functional implications in normal development and diverse diseases. 

More specifically, his laboratory is keen on developing experimental sequencing tools—SHARE-seq, MID-RRBS, SurfaceChIP-seq, and Spatial-ATAC-seq—to map the epigenomes and transcriptomes within rare populations, single-cells or in situ (Nature 2023; Cell 2023; Nature 2022; Cell 2020; Sci. Adv. 2018; Nat. Biomed. Eng. 2018). They also build computational workflows (Nature Commun. 2020; Cell 2020; Nature Methods 2020; Cell Genomics 2022) and apply these tools to investigate cell fate determination and perturbed cell states, such as hair follicle regeneration (Nature 2021; Nature 2020), brain development (Nat. Neurosci. 2022), and tumor progression (Cancer Discovery 2021; Cancer Cell 2020).

Learn more about the Ma Laboratory.