Publications:21
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Sam Horng, MD, PhD
Neurology
About Me
Sam Horng, MD, PhD, received his B.A. in biology, summa cum laude, from Columbia University, then trained as a pre-doctoral fellow in clinical bioethics at the National Institutes of Health. He completed his MD and PhD degree at Harvard Medical School and the Massachusetts Institute of Technology, where his graduate research investigated how early patterning events specify different sensory areas of the thalamus and cortex.
Dr. Horng completed his medical internship at Yale New Haven Hospital and his neurology residency at Mount Sinai Hospital, where he served as chief resident and was awarded an R25 Research in Residency grant from the National Institutes of Health and a Leon Levy Neuroscience Fellowship from 2015 to 2017 to study mechanisms of blood-brain barrier breakdown in inflammatory brain disease.
Dr. Horng investigates the role of specialized blood-brain barrier cells called astrocytes in controlling immune cell entry into the brain during autoimmune attack. He recently published work featured on the cover of The Journal of Clinical Investigation, demonstrating for the first time, that astrocytes act as an inducible barrier to immune cell entry in the early stages of autoimmune attack.
His laboratory is now focused on identifying specific contact-mediated interactions between astrocytes and immune cells, hypothesizing that astrocytes activate immune cells and control subsequent steps in the process of autoimmune attack. He aims to translate this work towards treatment strategies for multiple sclerosis and other CNS autoimmune diseases.
Dr. Horng offers telemedicine appointments when appropriate. Please call his office to schedule a video visit.
The state of Florida requires out-of-state professionals who are registered to provide telehealth services to display a hyperlink to the Florida Department of Health telehealth web page. This allows Florida patients who are receiving medical care by telehealth to confirm the provider’s licensure and Florida registration.
Language
English
Position
ASSISTANT PROFESSOR | Neurology, Multiple Sclerosis, ASSISTANT PROFESSOR | Immunology & Immunotherapy
Hospital Affiliations
- Mount Sinai Beth Israel
- Mount Sinai Brooklyn
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Blood-Brain Barrier, Brain Imaging, Chemokines, Cytokines, Demyelination, Immunology, Multiple Sclerosis, Neuro-degeneration/protection, Neurobiology, Neurology, Neuroscience
Multi-Disciplinary Training Areas
Neuroscience [NEU]
Download the CVClinical Focus
- Demyelinating Disease
- Gadolinium Enhancing Lesions
- Lumbar Puncture
- Multiple Sclerosis
- Neuromyelitis Optica
- Neurosarcoidosis
Education
MD, Harvard Medical School
BA, Columbia University
PhD, Massachusetts Institute of Technology
Internship, Internal Medicine
Yale New Haven Hospital
Residency, Neurology
Mount Sinai School of Medicine
Fellowship, Neuroimmunology, Multiple Sclerosis
Mount Sinai School of Medicine
Certifications
American Board of Psychiatry and Neurology
Awards
2018
K08 Mentored Clinical Scientist Research Career Development Award
National Institute of Neurological Diseases and Stroke
2015
Research Fellowship in Neuroscience
Leon Levy Foundation
2012
Arnold P. Gold Foundation’s Humanism and Excellence in Teaching Award
Department of Medical Education at the Icahn School of Medicine at Mount Sinai
2008
F30 Predoctoral NRSA Fellowship
National Institute of Neurological Diseases and Stroke
Research
The Horng Laboratory
Clinical disability in multiple sclerosis (MS) is driven by immune cell infiltration into the CNS parenchy-ma. Understanding the mechanisms by which CNS barrier cells regulate immune cell activation and en-try during this infiltrative process may identify novel therapeutic strategies for MS and other CNS auto-immune diseases.
During CNS inflammation, immune cells traffic from the blood through a two-barrier structure termed the neurovascular unit. While many have focused on entry through the first barrier, a specialized en-dothelial wall known as the blood-brain barrier, less is known about how immune cells interact with the second barrier, a layer of endfoot processes extending from specialized cells called astrocytes, a barrier referred to as the glia limitans. In MS lesions, immune cells circulate within the space between the first and second barriers, a compartment termed the perivascular space. Within this space, immune cells interact with the astrocyte endfeet and potentially receive signals that prime them for autoimmune attack.
The Horng Laboratory is interested in identifying and characterizing the signaling pathways between astrocytes and immune cells within the perivascular spaces. We are testing the hypothesis that this cross-talk regulates immune cell function prior to CNS entry and induces functional differentiation in both cell types which contributes to both the acute phase of CNS inflammation and more chronic processes of neurodegeneration.
Insurance Information
Accepted insurance may vary by the doctor’s office location. Please contact the office directly to obtain the most up-to-date insurance information.
- 1199 SEIU
- AETNA - Commercial
- AETNA - Medicare
- Affinity Medicaid-Medicare-Essential Exchange
- Amidacare Medicaid
- CIGNA Healthcare
- Centivo
- Elderplan
- EmblemHealth - GHI-PPO
- EmblemHealth - HIP
- EmblemHealth - HIP-Medicaid
- EmblemHealth - HIP-Medicare
- Empire Blue Cross Blue Shield - Commercial/Exchange
- Empire Blue Cross Blue Shield - HealthPlus Medicaid
- Empire Blue Cross Blue Shield - Medicare
- Fidelis Health Care
- HealthFirst Medicaid
- HealthFirst Medicare
- Horizon NJ
- Magnacare-Health Care
- Medicare - NJ
- Medicare - NY
- Metroplus
- Multiplan PHCS
- NJ Medicaid
- NY Medicaid
- Oscar
- Oxford - Freedom and Liberty
- Partners Health Plan
- Senior Whole Health
- United Health Care - Commercial
- United Health Care - Empire Plan
- United Health Care - Oxford Care
- United Health Care - Top Tier
- VNSNY Choice Medicare
- VNSNY Select Health Medicaid
- VillageCareMax
- WellCare Health Plan
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.
Publications
Selected Publications
- Aldh1l1-Cre/ERT2 Drives Flox-Mediated Recombination in Peripheral and CNS Infiltrating Immune Cells in Addition to Astrocytes During CNS Autoimmune Disease. Mario Amatruda, Juan Turati, Josh Weiss, Jorge Villavicencio, Zhihong Chen, Graham Britton, Sam Horng. Brain and Behavior
- Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis. Pierre Mora, Margaux Laisné, Célia Bourguignon, Paul Rouault, Béatrice Jaspard-Vinassa, Marlène Maître, Alain Pierre Gadeau, Marie Ange Renault, Sam Horng, Thierry Couffinhal, Candice Chapouly. Journal of Neuroinflammation
- Evaluation of immunological responses to third COVID-19 vaccine among people treated with sphingosine receptor-1 modulators and anti-CD20 therapy. Ilana Katz Sand, Sacha Gnjatic, Florian Krammer, Kevin Tuballes, Juan Manuel Carreño, Sammita Satyanarayan, Susan Filomena, Erin Staker, Johnstone Tcheou, Aaron Miller, Michelle Fabian, Neha Safi, Jamie Nichols, Jasmin Patel, Stephen Krieger, Stephanie Tankou, Sam Horng, Sylvia Klineova, Erin Beck, Miriam Merad, Fred Lublin. Multiple Sclerosis and Related Disorders
Patient Experience Star Ratings and Comments
The Patient Experience Star Rating reflects our patients’ perception of how well their Mount Sinai provider communicated with them during an office visit. The Star Rating is based on patient responses to three questions on a patient experience survey, a standardized questionnaire sent to verified patients and distributed by a third party vendor, Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score.
Care Provider’s Explanation
5 out of 5
Care Provider’s Concern
5 out of 5
Likelihood to Recommend Care Provider
5 out of 5
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Horng has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.