Samir Parekh - Cancer (Oncology) | Mount Sinai

About Me

Dr. Samir Parekh, MD is Professor (with tenure) of Medicine (Hematology and Medical Oncology) and Oncological Sciences. He is the Director of Translational Research in Myeloma and co-leader of the Cancer Clinical Investigation program at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. He is also a faculty member of the Icahn Genomics Institute.

Dr. Parekh's research focuses on the pathogenesis of hematological malignancies and development of individualized, precision-medicine therapies for these malignancies. His lab uses an integrated systems biology approach to study genome-wide methylation, gene expression and DNA sequence variation to understand pathogenesis, develop biomarkers and guide personalized therapy in B cell malignancies, particularly Multiple Myeloma and Non-Hodgkin's lymphoma.

Dr. Parekh has served on numerous review and advisory committees. He has successfully secured several federal and foundation grants and has authored multiple peer-reviewed publications.

Language

English

Position

PROFESSOR | Medicine, Hematology and Medical Oncology, PROFESSOR | Oncological Sciences

Hospital Affiliations

Mount Sinai Beth Israel
Mount Sinai Morningside
Mount Sinai Brooklyn
Mount Sinai Queens
The Mount Sinai Hospital
Mount Sinai West

Research Topics

Computational Biology, Drug Resistance, Epigenetics, Lymphoma, Transcriptional Activation and Repression

Multi-Disciplinary Training Areas

Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)

About Me

Dr. Samir Parekh, MD is Professor (with tenure) of Medicine (Hematology and Medical Oncology) and Oncological Sciences. He is the Director of Translational Research in Myeloma and co-leader of the Cancer Clinical Investigation program at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. He is also a faculty member of the Icahn Genomics Institute.

Dr. Parekh's research focuses on the pathogenesis of hematological malignancies and development of individualized, precision-medicine therapies for these malignancies. His lab uses an integrated systems biology approach to study genome-wide methylation, gene expression and DNA sequence variation to understand pathogenesis, develop biomarkers and guide personalized therapy in B cell malignancies, particularly Multiple Myeloma and Non-Hodgkin's lymphoma.

Dr. Parekh has served on numerous review and advisory committees. He has successfully secured several federal and foundation grants and has authored multiple peer-reviewed publications.

Language

English

Position

PROFESSOR | Medicine, Hematology and Medical Oncology, PROFESSOR | Oncological Sciences

Hospital Affiliations

Mount Sinai Beth Israel
Mount Sinai Morningside
Mount Sinai Brooklyn
Mount Sinai Queens
The Mount Sinai Hospital
Mount Sinai West

Research Topics

Computational Biology, Drug Resistance, Epigenetics, Lymphoma, Transcriptional Activation and Repression

Multi-Disciplinary Training Areas

Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)

Clinical Focus

Lymphoma
Multiple Myeloma

Education

MBBS, KJ Somaiya Medical College

Residency, Internal Medicine

John H Stroger Jr Hospital of Cook County

Fellowship, Hematology & Oncology

Montefiore/Albert Einstein College of Medicine Rheumatology

Awards

2005

Young Investigator Award

ASCO

Young Investigator Travel Award

ECOG

First Overall and Highest Rank in General Internal Medicine

K.J. Somaiya Medical College

Research

MCL is a rare and incurable non-Hodgkins lymphoma whose pathogenesis is not clearly understood. The SOX11 transcription factor is overexpressed in the majority of Mantle cell lymphomas. We identified the direct DNA binding targets of SOX11 in several oncogenic pathways using ChIP-sequencing and functional genomics and have now developed an inducible mouse model of SOX11 overexpression that recapitulates the MCL phenotype. We are developing anti-SOX11 small molecules with structural biologist Dr. Aneel Aggarwal at Mount Sinai that could be applicable in MCL and other SOX11 expressing tumors like lung cancer, ovarian cancer and glioma.

Visit the Parekh Laboratory

Locations

Ruttenberg Treatment Center

1470 Madison Avenue, 3rd Floor, New York, NY, 10029

212-241-7873

Insurance Information

Accepted insurance may vary by the doctor’s office location. Please contact the office directly to obtain the most up-to-date insurance information.

Ruttenberg Treatment Center1470 Madison Avenue, 3rd Floor, New York, NY, 10029

Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).

Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.

Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.

Publications

Publications:108

Selected Publications

View All Publications

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Parekh during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Other activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Amgen Inc. / Pfizer Inc. Partnership
Celgene Corporation

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Samir Parekh, MBBS

Cancer (Oncology), Hematology-Oncology

About Me

Language

Position

Hospital Affiliations

Research Topics

Multi-Disciplinary Training Areas

About Me

Language

Position

Hospital Affiliations

Research Topics

Multi-Disciplinary Training Areas

About Me

Language

Position

Hospital Affiliations

Research Topics

Multi-Disciplinary Training Areas

Clinical Focus

Video

Education

MBBS, KJ Somaiya Medical College

Residency, Internal Medicine

Fellowship, Hematology & Oncology

Awards

Research

Locations

Ruttenberg Treatment Center

Insurance Information

Publications

Selected Publications

Industry Relationships