Samuel E Gandy, MD, PhD
Sam Gandy, MD, PhD, is Mount Sinai Professor of Alzheimer's Disease Research, Professor of Neurology and Psychiatry, Associate Director of the Mount Sinai Alzheimer's Disease Research Center in New York City, and Chairman Emeritus of the National Medical and Scientific Advisory Council of the Alzheimer's Association. Dr. Gandy is an international expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 250 original papers, chapters, and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986.
Dr. Gandy is studying new methods for using blood and brain imaging biomarkers to diagnose chronic traumatic encephalopathy (CTE) during life in athletes retired from collision sports and in former warfighters exposed to improvised explosive device blast injuries on the battlefield. Dr. Gandy is also testing new classes of drugs aimed at relieving brain trauma-related neuropsychiatric syndromes such as post-traumatic stress disorder (PTSD).
Dr. Gandy is a member of the Faculty of 1000 Biology and serves as a consulting editor for The Journal of Clinical Investigation. He also serves on the editorial advisory boards for the journals Public Library of Science-Medicine (PLoSM), Neurodegenerative Diseases, and Current Alzheimer Research. He is associate editor of the journals Molecular Neurodegeneration and Alzheimer Disease and Associated Disorders. From 1996-2006, Dr Gandy was Director of the Cold Spring Harbor Laboratories/Wellcome Trust Annual Summer Course on the Neurobiology of Human Neurological Disorders. In 2000, he became chief organizer for the Cold Spring Harbor Laboratories Bi-Annual Winter Biotechnology Conference on Therapeutic Opportunities in Neurodegenerative Diseases and continues in that role until 2010.
Dr. Gandy has appeared numerous times on television and in print, including:
- Mount Sinai Queens
- The Mount Sinai Hospital
Alzheimer's Disease, Biochemistry, Biomedical Sciences, Biophysics, Brain, Brain Imaging, Cell Biology, Cognitive Neurology, Cognitive Neuroscience, Drug Design and Discovery, Genetics, Genomics, Hippocampus, Hormones, IGF-1 Receptor, Immunology, Induced pluripotent stem cells, Inflammation, Interferon, Intracellular Transport, Lipid Signaling, Lysosomes/endosome, Macrophage, Mass Spectrometry, Memory, Metabolism, Microglia, Neuro-degeneration/protection, Neurobiology, Neurology, Neuronal Regeneration, Neuroscience, Neurotoxicology, Neurotransmitters, Personalized Medicine, Pharmacogenomics, Pharmacology, Phosphorylation, Positron Emission Tomography, Prefrontal Cortex, Proteases, Protein Complexes, Protein Degradation, Protein Folding, Protein Kinases, Protein Phosphatases, Protein Structure/Function, Protein Trafficking & Sorting, Proteomics, Psychiatry, Receptors, Regeneration, Stem Cells, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Biology, T Cells, Trafficking, Viruses and Virology
Multi-Disciplinary Training Areas
Genetics and Genomic Sciences [GGS], Neuroscience [NEU]