Publications:350
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About Me
Sam Gandy, MD, PhD, is Mount Sinai Professor of Alzheimer's Disease Research, Professor of Neurology and Psychiatry, Associate Director of the Mount Sinai Alzheimer's Disease Research Center in New York City, and Chairman Emeritus of the National Medical and Scientific Advisory Council of the Alzheimer's Association. Dr. Gandy is an international expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 250 original papers, chapters, and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986.
Dr. Gandy is studying new methods for using blood and brain imaging biomarkers to diagnose chronic traumatic encephalopathy (CTE) during life in athletes retired from collision sports and in former warfighters exposed to improvised explosive device blast injuries on the battlefield. Dr. Gandy is also testing new classes of drugs aimed at relieving brain trauma-related neuropsychiatric syndromes such as post-traumatic stress disorder (PTSD).
Dr. Gandy is a member of the Faculty of 1000 Biology and serves as a consulting editor for The Journal of Clinical Investigation. He also serves on the editorial advisory boards for the journals Public Library of Science-Medicine (PLoSM), Neurodegenerative Diseases, and Current Alzheimer Research. He is associate editor of the journals Molecular Neurodegeneration and Alzheimer Disease and Associated Disorders. From 1996-2006, Dr Gandy was Director of the Cold Spring Harbor Laboratories/Wellcome Trust Annual Summer Course on the Neurobiology of Human Neurological Disorders. In 2000, he became chief organizer for the Cold Spring Harbor Laboratories Bi-Annual Winter Biotechnology Conference on Therapeutic Opportunities in Neurodegenerative Diseases and continues in that role until 2010.
Dr. Gandy has appeared numerous times on television and in print, including:
- http://www.castleconnolly.com/doctors/profiles/sam-gandy-neurology/
- https://www.facebook.com/mountsinainyc/videos/watch-our-qa-with-dr-sam-gandy-on-normal-signs-of-aging-vs-alzheimersdisease-spo/1540129759351270/
- https://www.eurekalert.org/pub_releases/2018-06/tmsh-uhl061118.php
- https://curealz.org/news-and-events/sam-gandy-m-d-ph-d-on-stem-cells/
- https://vimeo.com/236033738
- https://www.cbsnews.com/news/60-minutes-scientists-seek-veterans-for-final-act-of-service/
Dr. Gandy was featured with other prominent research scientists as GQ's "Rockstars of Science". View the PDF. In addition, Dr. Gandy has spoken before Congress on several occasions.
Dr. Gandy received both his MD and PhD at the Medical University of South Carolina. He completed an internship in internal medicine at the Columbia University College of Physicians & Surgeons and a residency in neurology at Cornell University Medical College. Dr. Gandy completed postdoctoral training at The Rockefeller University, where, in 1991, he was appointed assistant professor in the laboratory of Paul Greengard, 2000 Laureate of the Nobel Prize in Physiology or Medicine. From 1992-1997, Gandy was Associate Professor of Neurology and Neuroscience at Cornell University Medical College. From 1997-2001, he was Professor of Psychiatry and of Cell Biology at New York University and The Nathan S. Kline Institute for Psychiatric Research. From 2001-2007, heserved as Paul C. Brucker, M.D., Professor of Neuroscience at Jefferson Medical College and Founding Director of the Farber Institute for Neurosciences. In 2007, he assumed his current post as Mount Sinai Professor of Alzheimer's Disease Research at the Icahn School of Medicine at Mount Sinai. Dr. Gandy offers telemedicine appointments when appropriate. Please call his office to schedule a video visit. The state of Florida requires out-of-state professionals who are registered to provide telehealth services to display a hyperlink to the Florida Department of Health telehealth web page. This allows Florida patients who are receiving medical care by telehealth to confirm the provider’s licensure and Florida registration.Language
Position
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Alzheimer's Disease, Biochemistry, Biomedical Sciences, Biophysics, Brain, Brain Imaging, Cell Biology, Cognitive Neurology, Cognitive Neuroscience, Drug Design and Discovery, Genetics, Genomics, Hippocampus, Hormones, IGF-1 Receptor, Immunology, Induced pluripotent stem cells, Inflammation, Interferon, Intracellular Transport, Lipid Signaling, Lysosomes/endosome, Macrophage, Mass Spectrometry, Memory, Metabolism, Microglia, Neuro-degeneration/protection, Neurobiology, Neurology, Neuronal Regeneration, Neuroscience, Neurotoxicology, Neurotransmitters, Personalized Medicine, Pharmacogenomics, Pharmacology, Phosphorylation, Positron Emission Tomography, Prefrontal Cortex, Proteases, Protein Complexes, Protein Degradation, Protein Folding, Protein Kinases, Protein Phosphatases, Protein Structure/Function, Protein Trafficking & Sorting, Proteomics, Psychiatry, Receptors, Regeneration, Stem Cells, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Biology, T Cells, Trafficking, Viruses and Virology
Multi-Disciplinary Training Areas
Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
About Me
Sam Gandy, MD, PhD, is Mount Sinai Professor of Alzheimer's Disease Research, Professor of Neurology and Psychiatry, Associate Director of the Mount Sinai Alzheimer's Disease Research Center in New York City, and Chairman Emeritus of the National Medical and Scientific Advisory Council of the Alzheimer's Association. Dr. Gandy is an international expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 250 original papers, chapters, and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986.
Dr. Gandy is studying new methods for using blood and brain imaging biomarkers to diagnose chronic traumatic encephalopathy (CTE) during life in athletes retired from collision sports and in former warfighters exposed to improvised explosive device blast injuries on the battlefield. Dr. Gandy is also testing new classes of drugs aimed at relieving brain trauma-related neuropsychiatric syndromes such as post-traumatic stress disorder (PTSD).
Dr. Gandy is a member of the Faculty of 1000 Biology and serves as a consulting editor for The Journal of Clinical Investigation. He also serves on the editorial advisory boards for the journals Public Library of Science-Medicine (PLoSM), Neurodegenerative Diseases, and Current Alzheimer Research. He is associate editor of the journals Molecular Neurodegeneration and Alzheimer Disease and Associated Disorders. From 1996-2006, Dr Gandy was Director of the Cold Spring Harbor Laboratories/Wellcome Trust Annual Summer Course on the Neurobiology of Human Neurological Disorders. In 2000, he became chief organizer for the Cold Spring Harbor Laboratories Bi-Annual Winter Biotechnology Conference on Therapeutic Opportunities in Neurodegenerative Diseases and continues in that role until 2010.
Dr. Gandy has appeared numerous times on television and in print, including:
- http://www.castleconnolly.com/doctors/profiles/sam-gandy-neurology/
- https://www.facebook.com/mountsinainyc/videos/watch-our-qa-with-dr-sam-gandy-on-normal-signs-of-aging-vs-alzheimersdisease-spo/1540129759351270/
- https://www.eurekalert.org/pub_releases/2018-06/tmsh-uhl061118.php
- https://curealz.org/news-and-events/sam-gandy-m-d-ph-d-on-stem-cells/
- https://vimeo.com/236033738
- https://www.cbsnews.com/news/60-minutes-scientists-seek-veterans-for-final-act-of-service/
Dr. Gandy was featured with other prominent research scientists as GQ's "Rockstars of Science". View the PDF. In addition, Dr. Gandy has spoken before Congress on several occasions.
Dr. Gandy received both his MD and PhD at the Medical University of South Carolina. He completed an internship in internal medicine at the Columbia University College of Physicians & Surgeons and a residency in neurology at Cornell University Medical College. Dr. Gandy completed postdoctoral training at The Rockefeller University, where, in 1991, he was appointed assistant professor in the laboratory of Paul Greengard, 2000 Laureate of the Nobel Prize in Physiology or Medicine. From 1992-1997, Gandy was Associate Professor of Neurology and Neuroscience at Cornell University Medical College. From 1997-2001, he was Professor of Psychiatry and of Cell Biology at New York University and The Nathan S. Kline Institute for Psychiatric Research. From 2001-2007, heserved as Paul C. Brucker, M.D., Professor of Neuroscience at Jefferson Medical College and Founding Director of the Farber Institute for Neurosciences. In 2007, he assumed his current post as Mount Sinai Professor of Alzheimer's Disease Research at the Icahn School of Medicine at Mount Sinai. Dr. Gandy offers telemedicine appointments when appropriate. Please call his office to schedule a video visit. The state of Florida requires out-of-state professionals who are registered to provide telehealth services to display a hyperlink to the Florida Department of Health telehealth web page. This allows Florida patients who are receiving medical care by telehealth to confirm the provider’s licensure and Florida registration.Language
Position
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Alzheimer's Disease, Biochemistry, Biomedical Sciences, Biophysics, Brain, Brain Imaging, Cell Biology, Cognitive Neurology, Cognitive Neuroscience, Drug Design and Discovery, Genetics, Genomics, Hippocampus, Hormones, IGF-1 Receptor, Immunology, Induced pluripotent stem cells, Inflammation, Interferon, Intracellular Transport, Lipid Signaling, Lysosomes/endosome, Macrophage, Mass Spectrometry, Memory, Metabolism, Microglia, Neuro-degeneration/protection, Neurobiology, Neurology, Neuronal Regeneration, Neuroscience, Neurotoxicology, Neurotransmitters, Personalized Medicine, Pharmacogenomics, Pharmacology, Phosphorylation, Positron Emission Tomography, Prefrontal Cortex, Proteases, Protein Complexes, Protein Degradation, Protein Folding, Protein Kinases, Protein Phosphatases, Protein Structure/Function, Protein Trafficking & Sorting, Proteomics, Psychiatry, Receptors, Regeneration, Stem Cells, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Biology, T Cells, Trafficking, Viruses and Virology
Multi-Disciplinary Training Areas
Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
Clinical Focus
- Alzheimer's Disease
- Aphasia
- Apraxia
- Cognitive Impairment (Post Head Injury)
- Cognitive or Memory Impairment / Dementia
- Confused Memory
- Confusion (Post Head Injury)
- Delirium
- Dementia
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Video
Education
MD, scu
MD, PhD, Medical University of South Carolina
Internship, Internal Medicine
Columbia University Irving Medical Center
Residency, Neurology
New York Presbyterian Hospital-Weill Cornell
Certifications
American Board of Psychiatry and Neurology
Awards
2008
Arthur Cherkin Memorial Award in Geriatric Medicine
Locations
Insurance Information
Accepted insurance may vary by the doctor’s office location. Please contact the office directly to obtain the most up-to-date insurance information.
Patients with Cigna Medicare Advantage or Humana Medicare Advantage insurance: Please read this important message before booking to find out if out-of-network costs may apply to your next visit.
- Center for Cognitive Health5 East 98th Street, 7th Floor, New York, NY, 10029
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.
Publications
Selected Publications
- Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study. Minos Kritikos, Juin Wan Zhou, Chuan Huang, Sam Gandy, Alison C. Pellecchia, Stephanie Santiago-Michels, Melissa A. Carr, Shabab Islam, Yuan Yang, Megan K. Horton, Roberto G. Lucchini, Ana M. Franceschi, Lev Bangiyev, Paul Vaska, Sean Ap Clouston, Benjamin J. Luft. Journal of Alzheimer's Disease
- Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice. Matthew G. Engel, Sushma Narayan, Min Hui Cui, Craig A. Branch, Xusheng Zhang, Samuel E. Gandy, Michelle Ehrlich, Derek M. Huffman. Journal of Alzheimer's Disease
- Alzheimer's disease-associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain. Benjamin P. Readhead, Diego F. Mastroeni, Qi Wang, Maria A. Sierra, Camila de Ávila, Tajudeen O. Jimoh, Jean Vianney Haure-Mirande, Kristina E. Atanasoff, Jennifer Nolz, Crystal Suazo, Nathaniel J. Barton, Adrian R. Orszulak, Samantha M. Chigas, Khanh Tran, Anne Mirza, Krista Ryon, Jacqueline Proszynski, Deena Najjar, Joel T. Dudley, Sean T.H. Liu, Sam Gandy, Michelle E. Ehrlich, Eric Alsop, Jerry Antone, Rebecca Reiman, Cory Funk, Rebecca L. Best, Michael Jhatro, Kathy Kamath, John Shon, Timothy F. Kowalik, David A. Bennett, Winnie S. Liang, Geidy E. Serrano, Thomas G. Beach, Kendall Van Keuren-Jensen, Christopher E. Mason, Yingleong Chan, Elaine T. Lim, Domenico Tortorella, Eric M. Reiman. Alzheimer's and Dementia
Patient Experience Star Ratings and Comments
The Patient Experience Star Rating reflects our patients’ perception of how well their Mount Sinai provider communicated with them during an office visit. The Star Rating is based on patient responses to three questions on a patient experience survey, a standardized questionnaire sent to verified patients and distributed by a third party vendor, Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Gandy has not yet completed reporting of Industry relationships.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Gandy has not yet completed reporting of Industry relationships.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.