
Schahram Akbarian, MD, PhD
About Me
Schahram Akbarian studied medicine and conducted his thesis work on the central representation of the primate vestibular system at the Freie Universitaet Berlin, Germany. He is a board certified psychiatrist and molecular neuroscientist who trained at the Massachusetts General Hospital in Boston, the Whitehead Institute for Biomedical Research in Cambridge and the University of California at Irvine. In 2002, he joined the University of Massachusetts Medical School in Worcester where he established a research program in psychiatric epigenetics and served as the Director of the Brudnick Neuropsychiatric Research Institute. Presently, he heads the Division of Psychiatric Epigenomics in the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine.
He is a former recipient of the Klerman award from the Brain & Behavior Research Foundation, the Judith Silver Memorial award of the National Alliance for the Mentally Ill, the Outstanding resident award of the National Institute of Mental Health and the Eva King Killam Research Award of the American College of Neuropsychopharmacology. Dr. Akbarian has been a principal investigator on National Institutes of Health-funded research projects and grants since 2001and published close to 100 articles in scientific journals and book chapters. He is a member of professional societies such as the American College of Neuropsychopharmacology (ACNP) and presently serves on the Scientific Advisory Board of the Brain & Behavior Research Foundation (BBRF, formerly NARSAD), the American Foundation for Suicide Prevention and the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). He serves on Editorial Boards of various journals in the field, including Biological Psychiatry, Neuropsychopharmacology, Schizophrenia Bulletin and European Neuropsychopharmacology.
Visit Dr. Akbarian's Laboratory of Epigenetic Regulation of the Human Brain and Mount Sinai Conte Center on Epigenetic Mechanisms of Depression for more information.
Language
English
Position
PROFESSOR | Genetics and Genomic Sciences, PROFESSOR | Neuroscience, PROFESSOR | Psychiatry
Research Topics
Depression, Schizophrenia
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
Research
Key words: nucleosome, epigenome, histone methylation, neuronal nucleus, prefrontal cortex, mood disorder, schizophrenia, autism spectrum disorder
Publications
Selected Publications
- Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia. Alyssa M. Wilson, Michelle M. Jacobs, Tova Y. Lambert, Aditi Valada, Gregory Meloni, Evan Gilmore, Jacinta Murray, Susan Morgello, Schahram Akbarian. Nature Communications
- A map of enhancer regions in primary human neural progenitor cells using capture STARR-seq. Sophia C. Gaynor-Gillett, Lijun Cheng, Manman Shi, Jason Liu, Gaoyuan Wang, Megan Spector, Qiuyu Guo, Le Qi, Mary Flaherty, Martha Wall, Ahyeon Hwang, Mengting Gu, Zhanlin Chen, Yuhang Chen, Jennifer R. Moran, Jing Zhang, Donghoon Lee, Mark Gerstein, Daniel H. Geschwind, Kevin P. White, Schahram Akbarian, Alexej Abyzov, Nadav Ahituv, Dhivya Arasappan, Jose Juan Almagro Armenteros, Brian J. Beliveau, Jaroslav Bendl, Sabina Berretta, Rahul A. Bharadwaj, Arjun Bhattacharya, Lucy Bicks, Kristen Brennand, Davide Capauto, Frances A. Champagne, Tanima Chatterjee, Chris Chatzinakos, Andrew Chess, Nikolaos P. Daskalakis, John F. Fullard, Kiran Girdhar, Vahram Haroutunian, Gabriel E. Hoffman, Alex Kozlenkov, Dalila Pinto, Towfique Raj, Panos Roussos, Robert Sebra, Harm van Bakel, Georgios Voloudakis, Biao Zeng. Genome Research
- Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression. Anjali Chawla, Doruk Cakmakci, Laura M. Fiori, Wenmin Zang, Malosree Maitra, Jennie Yang, Dariusz Żurawek, Gabriella Frosi, Reza Rahimian, Haruka Mitsuhashi, Maria Antonietta Davoli, Ryan Denniston, Gary Gang Chen, Volodymyr Yerko, Deborah Mash, Kiran Girdhar, Schahram Akbarian, Naguib Mechawar, Matthew Suderman, Yue Li, Corina Nagy, Gustavo Turecki. Nature Genetics