Publications:251
Schahram Akbarian, MD, PhD
About Me
Schahram Akbarian studied medicine and conducted his thesis work on the central representation of the primate vestibular system at the Freie Universitaet Berlin, Germany. He is a board certified psychiatrist and molecular neuroscientist who trained at the Massachusetts General Hospital in Boston, the Whitehead Institute for Biomedical Research in Cambridge and the University of California at Irvine. In 2002, he joined the University of Massachusetts Medical School in Worcester where he established a research program in psychiatric epigenetics and served as the Director of the Brudnick Neuropsychiatric Research Institute. Presently, he heads the Division of Psychiatric Epigenomics in the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine.
He is a former recipient of the Klerman award from the Brain & Behavior Research Foundation, the Judith Silver Memorial award of the National Alliance for the Mentally Ill, the Outstanding resident award of the National Institute of Mental Health and the Eva King Killam Research Award of the American College of Neuropsychopharmacology. Dr. Akbarian has been a principal investigator on National Institutes of Health-funded research projects and grants since 2001and published close to 100 articles in scientific journals and book chapters. He is a member of professional societies such as the American College of Neuropsychopharmacology (ACNP) and presently serves on the Scientific Advisory Board of the Brain & Behavior Research Foundation (BBRF, formerly NARSAD), the American Foundation for Suicide Prevention and the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). He serves on Editorial Boards of various journals in the field, including Biological Psychiatry, Neuropsychopharmacology, Schizophrenia Bulletin and European Neuropsychopharmacology.
Visit Dr. Akbarian's Laboratory of Epigenetic Regulation of the Human Brain and Mount Sinai Conte Center on Epigenetic Mechanisms of Depression for more information.
Language
English
Position
PROFESSOR | Genetics and Genomic Sciences, PROFESSOR | Neuroscience, PROFESSOR | Psychiatry
Research Topics
Depression, Schizophrenia
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
Research
Dr. Akbarian’s research interests include epigenetic determinants of normal and diseased human brain development, with implications for the neurobiology of major psychiatric disorders such as schizophrenia, autism and depression. This work is largely focused on charting DNA and histone modification landscapes, and more generally, genome organization, in specific cell types from brain. These clinical studies are complemented by preclinical research, exploring novel avenues for treatment of psychiatric disease in cell cultures and animal models with specific mutations in proteins regulating chromatin and chromosomal architectures.
Key words: nucleosome, epigenome, histone methylation, neuronal nucleus, prefrontal cortex, mood disorder, schizophrenia, autism spectrum disorder
Key words: nucleosome, epigenome, histone methylation, neuronal nucleus, prefrontal cortex, mood disorder, schizophrenia, autism spectrum disorder
Publications
Selected Publications
- Functional implications of polygenic risk for schizophrenia in human neurons. P. J. Michael Deans, Kayla G. Retallick-Townsley, Aiqun Li, Carina Seah, Jessica Johnson, Judit Garcia Gonzalez, Evan Cao, Nadine Schrode, Alex Yu, Sam Cartwright, Georgios Voloudakis, Wen Zhang, Minghui Wang, John F. Fullard, Kiran Girdhar, Eli Stahl, Schahram Akbarian, Bin Zhang, Panos Roussos, Paul O’Reilly, Laura M. Huckins, Kristen J. Brennand. Nature Communications
- 3D genetic architecture of schizophrenia risk across three neuronal subtypes. Samuel K. Powell, Will Liao, Sadaf Ghorbani, Raymond Rigat, Callan O’Shea, Sarah Kammourh, Rahat Elahi, Dana Infante, PJ Michael Deans, Derek J. Le, Poonam Agarwal, Wei Qiang Seow, Novin Balafkan, Kevin C. Wang, Schahram Akbarian, Kristen J. Brennand. Molecular Psychiatry
- Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia. Alyssa M. Wilson, Michelle M. Jacobs, Tova Y. Lambert, Aditi Valada, Gregory Meloni, Evan Gilmore, Jacinta Murray, Susan Morgello, Schahram Akbarian. Nature Communications
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Akbarian has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.