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    Scott J Russo, PhD

    Education

    PhD, Graduate School and University Center of CUNY

    , University of Texas Southwestern Medical Center

    Awards

    2019

    Daniel H. Efron Basic Science Award from the

    American College of Neuropsychopharmacology

    2017

    Friedman Brain Institute Best Mentor Award

    Friedman Brain Institute

    2014

    Icahn School of Medicine at Mount Sinai Faculty Council Award

    2013

    Irma T. Hirschl/Monique Weill-Caulier Trust Research Award

    2012

    Johnson & Johnson/IMHRO Rising Star Translational Research Award

    2012

    Dr. Harold and Golden Lamport Research Award

    2012

    Mount Sinai School of Medicine “Best Postdoctoral Mentor” Award

    Research

    We have found that the pro-inflammatory cytokine interleukin-6 (IL-6) is highly up regulated in serum from stress susceptible mice as well as patients with treatment resistant major depression. The source of IL-6 is from bone marrow derived leukocytes, which is released in response to stress and can penetrate the brain and act directly on neural circuits controlling mood and emotion. In order to study peripheral IL-6, we’ve generated bone marrow chimeric mice that lacks the IL-6 gene only in bone marrow derived leukocytes and found the mice were behaviorally resilient to social stress. We also administered systemic monoclonal antibodies to sequester IL-6 and promote resilience. Janssen Pharmaceuticals partially funded our work testing such antibody sequestration strategies, and based on the results, they have recently launched a phase II clinical trial testing the efficacy of Sirukumab, a humanized monoclonal antibody against IL-6, in treatment resistant unipolar depression. Our current investigations aim to define the precise mechanisms by which peripheral immune cells and pro-inflammatory signals impact synaptic mechanisms in brain reward regions

    Publications