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    Scott J Russo, PhD

    Education

    PhD, Graduate School and University Center of CUNY

    , University of Texas Southwestern Medical Center

    Awards

    2019

    Daniel H. Efron Basic Science Award from the

    American College of Neuropsychopharmacology

    2017

    Friedman Brain Institute Best Mentor Award

    Friedman Brain Institute

    2014

    Icahn School of Medicine at Mount Sinai Faculty Council Award

    2013

    Irma T. Hirschl/Monique Weill-Caulier Trust Research Award

    2012

    Johnson & Johnson/IMHRO Rising Star Translational Research Award

    2012

    Dr. Harold and Golden Lamport Research Award

    2012

    Mount Sinai School of Medicine “Best Postdoctoral Mentor” Award

    Research

    A few years ago, we observed that highly aggressive mice found aggressive social interaction to be rewarding and we hypothesized that this may directly drive aggressive behavior. Using circuit tracing techniques and slice electrophysiology we identified key differences in the activation of brain reward circuitry between highly aggressive mice and their non-aggressive counterparts. Tools such as circuit specific optogenetics along with in vivo imaging of neural activity in awake behaving mice have allowed us to functionally probe neural circuits that control the rewarding aspects of aggressive behavior. Our initial results show strong activation of a GABAergic projection from the basal forebrain to the lateral habenula (lHb) that controls both aggression and its rewarding properties. Ongoing studies in my lab aim to further dissect the inputs to lHb impacting aggressive behavior and to identify the discreet neural codes associated with such aggressive behavior along with the molecular mechanisms driving these effects.