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    Scott J Russo, PhD

    Education

    PhD, Graduate School and University Center of CUNY

    , University of Texas Southwestern Medical Center

    Awards

    2019

    Daniel H. Efron Basic Science Award from the

    American College of Neuropsychopharmacology

    2017

    Friedman Brain Institute Best Mentor Award

    Friedman Brain Institute

    2014

    Icahn School of Medicine at Mount Sinai Faculty Council Award

    2013

    Irma T. Hirschl/Monique Weill-Caulier Trust Research Award

    2012

    Johnson & Johnson/IMHRO Rising Star Translational Research Award

    2012

    Dr. Harold and Golden Lamport Research Award

    2012

    Mount Sinai School of Medicine “Best Postdoctoral Mentor” Award

    Research

    My lab has made fundamental contributions to understanding how brain reward systems adapt to chronic stress and cocaine. Utilizing advanced histological techniques, whole cell electrophysiology and 2 photon glutamate uncaging at single spines, we have found that chronic stress or cocaine increases excitatory synaptic transmission within the nucleus accumbens (NAc) in a cell- and synapse-type specific manner to control depression- and addiction-like behaviors. More recently, we have investigated the role of specific presynaptic glutamatergic inputs to the NAc in meditating depression-like behavior using circuit specific optogenetics and electrophysiology. We have found that social defeat stress, a mouse model of depression, increases synaptic transmission specifically at thalamo-striatal synapses on NAc medium spiny neurons and that this is both necessary and sufficient to promote a depression-like behavioral phenotype.

    Publications