
- Mount Sinai Doctors
Scott L Friedman, MD
Internal Medicine, Gastroenterology
About Me
Language
English
Position
DEAN FOR COLLABORATIVE RESEARCH AND PARTNERSHIPS, PROFESSOR | Medicine, Liver Diseases, PROFESSOR | Pharmacological Sciences
Hospital Affiliations
- Mount Sinai Morningside
- Mount Sinai Queens
- The Mount Sinai Hospital
- Mount Sinai West
Research Topics
Aerodigestive Tract, Anti-Tumor Therapy, Apoptosis/Cell Death, Autophagy, Biomedical Sciences, Cancer Genetics, Cell Biology, Cell Transformation, Developmental Biology, Drug Resistance, Endothelial Cells, Epithelial Cells, Extracellular Matrix, Fibrosis, Gene Regulation, Growth Factors and Receptors, Hepatitis C Virus, Integrins, Knockout Mice, Liver, Macrophage, Metastasis, Molecular Biology, Organogenesis, Oxidative Stress, Phosphorylation, Proteases, Receptors, Signal Transduction, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice, Tumor Suppressor Genes, Tumorigenesis, Vascular Development, Wound Healing
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)
Video
Education
BS, Rensselaer Polytechnic Institute
MD, Icahn School of Medicine at Mount Sinai
Residency, Internal Medicine
Beth Israel Deaconess Medical Center
Residency, Internal Medicine
Beth Israel Deaconess Medical Center
Fellowship, Gastroenterology
University of CA at San Francisco Medical Center
Certifications
American Board of Internal Medicine
Awards
2016
Am Assn for the Study of Liver Diseases Distinguished Achievement Award
AASLD
2016
American Liver Foundation Distinguished Achievement Award
American Liver Foundation
2015
Emmet B Keeffe Mentoring Award
Recognizes outstanding mentorship in the field of hepatology
2015
Fellow, American Assn for the Advancement fo Science
AAAS
2015
Maud Menten Honorary Lecture
U. Pittsburgh
2015
Burton Combes Memorial Lecture
UT Southwestern GI Division
2015
Charles Lieber Memorial Lecture
American Gastroenterological Assn
2014
China Friendship Award
Chinese Government, presented by the Premier of China
2014
The Jacobi Medallion
The Icahn School of Medicine at Mount Sinai
2014
Salute to Excellence Award
American Liver Foundation, San Francisco Chapter
2014
Fellow
Am Assn for the Study of Liver Diseases
2014
President
American Assn for the Study of Liver Diseases
2014
Rao Honorary Lecture
Feinberg School of Medicine, Northwestern U.
2013
International Recognition Award
European Assn for the Study of LIver
2013
Shanghai Magnolia Gold Award
City of Shanghai
2012
Master Educator Recognition
Mount Sinai Institute for Medical Education
2010
Englert Lecture
University of Utah Dept of Medicine
2009
Rafael Research Alumni Visiting Scientist
Rambam Hospital, Haifa, Israel
2009
Sheila Sherlock Lecture
British Assn for Gastroenterology, Liverpool, UK
2008
Sackler Distinguished Lectureship
Tel Aviv University, Israel
2008
Fellow of the American Gastroenterological Assn
2008
Ken & Louise Goldberg Visiting Professor
Brigham and Women's Hospital, Boston MA
2006
Solomon Berson Dept of Medicine Housestaff Teaching Award
2004
International Hans Popper Research Prize
Falk foundation
2003
International Hans Popper Award to Outstanding Researcher in Hepatology
1995
Fulbright Senior Scholar Award
1979
Arthur H. Aufses Sr., Prize in Surgery
Mount Sinai School of Medicine
Research
Specific Clinical/Research Interest:
- Cellular and molecular mechanisms of hepatic fibrosis and cancer
- Diagnosis and development of anti-fibrotic therapies for patients with chronic liver disease
- Clinical trials of antifibrotic therapies in patients with chronic liver disease
Current Students: Billie Bian PhD Student, Fatemah Parvin-Nejad, MD Student; Benjamin Wooden, MD Student
Current Postdoctoral Fellows: Youngjoon Yoon, MD; Takuma Tsuchida PhD;
Research Personnel: Hsin Chou, M.S. (Lab Manager); Dipankar Bhattacharya, M.S.
Summary of Research Studies:
Our work explores the molecular mechanisms of wound healing and fibrosis in liver and how they contribute to liver cancer. We use a variety of animal and cell culture models to identify key inflammatory mediatiors and signaling molecules regulating the activation of hepatic stellate cells, the principle fibrogenic cells in liver. Additionally, we test candidate antifibrotic lead compounds to develop potential new therapies for patients with chronic fibrosing liver diseases. Specific projects include:
- Molecular mechanisms of hepatic stellate cell activation and the cell's role iin hepatic regeneration, immunity and repair
-Testing of antifibrotic lead compounds in animal models
-Clinical trials of antifibrotic therapies in patients with chronic liver disease
Insurance Information
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.
Publications
Selected Publications
- Hot and cold fibrosis: The role of serum biomarkers to assess immune mechanisms and ECM-cell interactions in human fibrosis. Andressa de Zawadzki, Diana J. Leeming, Arun J. Sanyal, Quentin M. Anstee, Jörn M. Schattenberg, Scott L. Friedman, Detlef Schuppan, Morten A. Karsdal. Journal of Hepatology
- EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis. Fanglin Ma, Miriam Longo, Marica Meroni, Dipankar Bhattacharya, Erika Paolini, Shama Mughal, Syed Hussain, Sumit Kumar Anand, Neha Gupta, Yiwei Zhu, Amaia Navarro-Corcuera, Kenneth Li, Satya Prakash, Bruno Cogliati, Shuang Wang, Xin Huang, Xiaobo Wang, Arif Yurdagul, Oren Rom, Liheng Wang, Susan K. Fried, Paola Dongiovanni, Scott L. Friedman, Bishuang Cai. Cell Metabolism
- Addressing the High and Rising Global Burden of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH): From the Growing Prevalence to Payors' Perspective. Zobair M. Younossi, Homie Razavi, Michael Sherman, Alina M. Allen, Quentin M. Anstee, Kenneth Cusi, Scott L. Friedman, Eric Lawitz, Jeffrey V. Lazarus, Detlef Schuppan, Manuel Romero-Gómez, Jörn M. Schattenberg, Miriam B. Vos, Vincent Wai Sun Wong, Vlad Ratziu, Marcus Hompesch, Arun J. Sanyal, Rohit Loomba. Alimentary Pharmacology and Therapeutics
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Below are financial relationships with industry reported by Dr. Friedman during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
- Boston Pharmaceuticals
- Curie Bio
- Mediar Therapeutics
- AGED Diagnostics
- Takeda Pharmaceuticals Of North America, Inc.
- InSitro
- Pfizer Pharmaceuticals
- Aditum Bio
- Gordian Biotechnology
- Surrozen
- AbbVie Biotherapeutics, Inc.
- Variant BIo
- Abalone Bio, Inc.
- Ochre Bio
- Junevity
- Sagimet Biosciences
- Merck & Co., Inc.
- Boehringer Ingelheim, Ltd.
- Moderna Therapeutics, Inc.
- Kriya
- Resolution Therapeutics
- Engine BIosciences
- Axelyf
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Junevity
- Mediar Therapeutics
- Sagimet Biosciences
- AGED Diagnostics
- InSitro
- Gordian Biotechnology
- Surrozen
- Abalone Bio, Inc.
- Ochre Bio
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.