Stephen Salton

Stephen Salton, MD, PhD

About Me

 

 

 

 

 

 

 

 

 

Research in the Salton lab is focused on understanding the mechanisms by which neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development, adult function, and the response to injury and neurodegenerative disease.

Language
English
Position
PROFESSOR | Neuroscience, PROFESSOR | Geriatrics and Palliative Medicine
Research Topics

Adipose, Aging, Apoptosis/Cell Death, Axon Guidance, Brain, Cell Adhesion, Chromogranins and Secretogranins, Cognitive Neuroscience, Cytoskeleton, Depression, Diabetes, Growth Cone, Growth Factors and Receptors, Hormones, Memory, Neuropeptides, Neurotrophins, Obesity, Protein Phosphatases, Protein Trafficking & Sorting, Signal Transduction, Synapses

Multi-Disciplinary Training Areas

Neuroscience [NEU]

Education

BA, University of Pennsylvania
Fellowship, Columbia Presbyterian and Mount Sinai School of Medicine
Internship and Residency, Bellevue and NYU School of Medicine
MD, New York University
PhD, New York University

Awards

2008

NARSAD van Ameringen Investigator

2006

NARSAD Independent Investigator

1994

Irma T. Hirschl Career Scientist

1991

Pew Scholar in the Biomedical Sciences

1989

Pfizer Scholar

1986

Pfizer Postdoctoral Fellow

Research

Specific Clinical/Research Interests:  Molecular Neuroscience; Neurotrophin Signaling; Neuropeptides; Neural Cell Adhesion Molecules; Obesity; Diabetes; Depression; Major Depressive Disorder; Alzheimer's Disease.

Summary of Research Studies: Our research is focused on understanding the mechanisms by which neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development and function. BDNF and NGF have been implicated in the pathophysiology of neurodegenerative disease, neuropsychiatric illness, CNS injury, and obesity. The contributions made by specific neurotrophin-regulated gene products to depression, memory, and energy balance, are being being examined using novel knockout, transgenic, and knockin mouse models. The lab has identified VGF, a secreted neuronal and neuroendocrine peptide precursor, and the cell adhesion molecule (CAM) L1 or NILE, as important gene products that are induced by neurotrophins including NGF and BDNF during neural differentiation and CNS/PNS development. Cultured neurons, neural and endocrine cell lines, hippocampal slices, and mouse models are all utilized to study effects of these proteins on synaptic plasticity, neurogenesis, axonal outgrowth, and axonal pathfinding. We are currently determining the signaling pathways, networks, and functional roles that these neurotrophin-regulated molecules play in clinically relevant diseases, including in major depressive disorder, neuropathic pain, obesity, and Alzheimer's disease.

Visit Dr. Stephen Salton's Lab for more information.

Locations

Publications

Publications:90
Selected Publications