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Terry F Davies, MD

Internal Medicine, Endocrine, Diabetes and Bone Diseases (Endocrinology)

212-241-3422
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Clinical Focus

Video

Education

MD, University of Newcastle-Upon-Tyne

MD, University of New Castle-Upon-Tyne

Residency, Internal Medicine

Newcastle University Medical School

Residency, Endocrinology, Diabetes and Metabolism

Newcastle University Medical School

Fellowship, Endocrinology, Diabetes and Metabolism

National Cancer Institute, NIH

Certifications

American Board of Internal Medicine

Awards

2009

Best Doctors

New York Magazine

2008

President Elect

American Thyroid Association

2008

Invited lecture

International Autoimmunity Conference, Porto, Portugal

2007

Honorary President for Life

United States Friends of Newcastle University

2006

Veterans Affairs Merit Award

2006

Invited Lecture

International Autoimmunity Congress, Sorrento, Italy

2006

Plenary Lecture

Canadian Society for Endocrinology, Toronto

2005

Plenary Lecture

German Endocrine Society, Muenster

2004

Plenary Lecture

4th International Congress on Autoimmunity, Budapest, Hungary

2003

Plenary Lecture

Australian Endocrine Society, Melbourne

2002

Higgins Award

Thyroid Foundation of America

Research

Specific Clinical/Research Interest:
Mechanisms in autoimmune disease with an emphasis on autoimmune thyroid disease

Postdoctoral Fellows: Marco Agote-Robertson PhD, Sayed Moshad PhD, Chris Michalek MD, PhD, Risheng Ma, PhD

Research Personnel: Rauf Latif PhD, Xiaoming Yin PhD, Zhong Yao

Summary of Research Studies:
Research areas of emphasis include: The TSH receptor molecule: This is the major autoantigen in human Graves' disease which is a form of autoimmune hyperthyroidism. The TSHR remains an elusive quarry ten years after it was cloned becsue of its highly complex processing. Our emphasis is on the post translational processing events involved with multimerization and intramolecular cleavage of the TSHR and its status in lipid rafts. Complex Genetics: The aim of this research has been to detect the susceptibility genes for autoimmune thyroid disease using genome screening of informative families with Graves' disease and/or Hashimoto's thyroiditis. Our group has experience in the analysis of families with these disorders and we have a large collection of well characterized families to study. Currently, our areas of emphasis are on individual susceptibility genes. In particular the TSH receptor intron 1 region where we have identified miRNAs close to associated SNPs and the role of epigenetics(using X chromosome inactivation) in disease susceptibility and its influence on the autoimmune response. Animal models of autoimmune thyroid disease: We have developed models of hyperthyroid mice immunized with an adenoviral vector incorporating the TSH receptor as a model for Graves' disease. These studies involve the development and characterization of unique monoclonal antibodies to the TSH receptor with thyroid stimulating activity with an emphasis on epitope characterization and signal transduction.

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