Publications:73
Thomas P Zwaka, MD, PhD
About Me
Dr. Zwaka’s research focuses on fundamental questions surrounding stem cell biology, including how to reverse the process of differentiation and “re-program” any given cell type into a pluripotent stem cell. Zwaka Lab website: https://www.zwakalab.org/
Language
English
Position
PROFESSOR | Stem Cell Biology And Regenerative Medicine
Research Topics
Apoptosis/Cell Death, Cell Biology, Developmental Biology, Embryology, Epigenetics, Gene Regulation, Gene Therapy, Stem Cells, Tissue Engineering, Transcription Factors, Transcriptional Activation and Repression
Multi-Disciplinary Training Areas
Development Regeneration and Stem Cells [DRS]
Education
MD PhD, University of Ulm
Postdoctoral, University of Wisconsin, Madison
Research
Retrotransposons can seriously damage the genome of the nascent embryo and cause sporadic diseases and infertility. Here we will explore a new sensing mechanism that involves early embryonic cells “sniffing” one another for endogenous retroviruses and the removal of cells that failed to silence their genetic parasites. Our line of investigation will provide new targets for genetic diagnosis and interventions targeting pregnancy loss, birth defects and childlessness.
Publications
Selected Publications
- Bats as instructive animal models for studying longevity and aging. Lisa Noelle Cooper, Mohammad Y. Ansari, Grace Capshaw, Alex Galazyuk, Amanda M. Lauer, Cynthia F. Moss, Karen E. Sears, Mark Stewart, Emma C. Teeling, Gerald S. Wilkinson, Rachel C. Wilson, Thomas P. Zwaka, Rena Orman. Annals of the New York Academy of Sciences
- Abortive infection of bat fibroblasts with SARS-CoV-2. Punam Bisht, Michael D. Gallagher, M. Inmaculada Barrasa, Julie Boucau, Alfred Harding, Marion Déjosez, Carlos Godoy-Parejo, Margaret E. Bisher, Giovanni de Nola, Abigail K.R. Lytton-Jean, Lee Gehrke, Thomas P. Zwaka, Rudolf Jaenisch. Proceedings of the National Academy of Sciences of the United States of America
- Advancing stem cell technologies for conservation of wildlife biodiversity. Ashlee M. Hutchinson, Ruth Appeltant, Tom Burdon, Qiuye Bao, Rhishikesh Bargaje, Andrea Bodnar, Stuart Chambers, Pierre Comizzoli, Laura Cook, Yoshinori Endo, Bob Harman, Katsuhiko Hayashi, Thomas Hildebrandt, Marisa L. Korody, Uma Lakshmipathy, Jeanne F. Loring, Clara Munger, Alex H.M. Ng, Ben Novak, Manabu Onuma, Sara Ord, Monique Paris, Andrew J. Pask, Francisco Pelegri, Martin Pera, Ryan Phelan, Benyamin Rosental, Oliver A. Ryder, Woranop Sukparangsi, Gareth Sullivan, Nicole Liling Tay, Nikki Traylor-Knowles, Shawn Walker, Antonia Weberling, Deanne J. Whitworth, Suzannah A. Williams, Jessye Wojtusik, Jun Wu, Qi Long Ying, Thomas P. Zwaka, Timo N. Kohler. Development (Cambridge)