Publications:37
Timothy A Blenkinsop, PhD
About Me
Timothy Blenkinsop's laboratory works to understand the basic biology of the adult human eye in an effort to reveal mechanisms for regeneration. We are currently focused on RPE and RPE related diseases. Our approach is to develop in vitro models of the adult human RPE layer from human donors with RPE related disease in order to more carefully study disease pathology and identify compounds that can improve disease progression. We also explore the epigenetic state of RPE in normal and pathological conditions in order to understand how the cell state is regulating gene expression. Finally, we are attempting to develop a transplantation method whereby healthy human RPE from donors can be transplanted into patients where RPE are damaged or lost to preserve or improve vision.
For more information, please visit the https://labs.icahn.mssm.edu/blenkinsoplab/ website.
Language
English
Position
ASSOCIATE PROFESSOR | Ophthalmology, ASSOCIATE PROFESSOR | Stem Cell Biology And Regenerative Medicine
Multi-Disciplinary Training Areas
Development Regeneration and Stem Cells [DRS], Disease Mechanisms and Therapeutics (DMT)
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PhD,BS, New York University,University of Wisconsin at Whitewater
Publications
Selected Publications
- IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration. Brigitte L. Arduini, Timothy A. Blenkinsop, Michael Naimark, Susan Borden, Carol Charniga, Melissa Campbell, Natasha Rugenstein, Richard J. Davis, Nazia Alam, Glen Prusky, Amber M. Frye, Francesca Mazzoni, Silvia C. Finnemann, Cuiping Zhao, Patricia Lederman, Janmeet S. Saini, Thomas R. Kiehl, Nicole Renga, Jade A. Kozak, Penny A. Rocchio, Enrique Salero, Nathan C. Boles, Susan K. Goderie, Steven Lotz, Joan E. Adamo, Sharyl Zaccaglino, Khadijah Onanuga, Michael Fiske, Alexandra Capela, Sally Temple, Jeffrey H. Stern. Cell Reports Medicine
- Putative Self-Organizing Human Corneal Organoids Recapitulate Human Corneal Architecture and Cellular Diversity. Timothy A. Blenkinsop, Anne Z. Eriksen. Bioengineering
- Neuroectoderm-derived iris muscle characterization at the single-cell resolution in native human iris and a pluripotent stem cell eye model. Bar Makovoz, Anne Z. Eriksen, Rachael E. Warrington, Damian Williams, Timothy A. Blenkinsop. Nature Communications
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Blenkinsop has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.