
Timothy A Blenkinsop, PhD
About Me
Timothy Blenkinsop's laboratory works to understand the basic biology of the adult human eye in an effort to reveal mechanisms for regeneration. We are currently focused on RPE and RPE related diseases. Our approach is to develop in vitro models of the adult human RPE layer from human donors with RPE related disease in order to more carefully study disease pathology and identify compounds that can improve disease progression. We also explore the epigenetic state of RPE in normal and pathological conditions in order to understand how the cell state is regulating gene expression. Finally, we are attempting to develop a transplantation method whereby healthy human RPE from donors can be transplanted into patients where RPE are damaged or lost to preserve or improve vision.
For more information, please visit the https://labs.icahn.mssm.edu/blenkinsoplab/ website.
Language
English
Position
ASSOCIATE PROFESSOR | Ophthalmology
Multi-Disciplinary Training Areas
Development Regeneration and Stem Cells [DRS], Disease Mechanisms and Therapeutics (DMT)
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PhD,BS, New York University,University of Wisconsin at Whitewater
Publications
Selected Publications
- Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report. Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig, Kapil Bharti. Stem Cell Research and Therapy
- A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway. Bhav Harshad Parikh, Zengping Liu, Paul Blakeley, Qianyu Lin, Malay Singh, Jun Yi Ong, Kim Han Ho, Joel Weijia Lai, Hanumakumar Bogireddi, Kim Chi Tran, Jason Y.C. Lim, Kun Xue, Abdurrahmaan Al-Mubaarak, Binxia Yang, R. Sowmiya, Kakkad Regha, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Zhongxing Zhang, Anand D. Jeyasekharan, Veluchamy Amutha Barathi, Weimiao Yu, Kang Hao Cheong, Timothy A. Blenkinsop, Walter Hunziker, Gopal Lingam, Xian Jun Loh, Xinyi Su. Nature Communications
- Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells. Elke K. Markert, Holger Klein, Coralie Viollet, Werner Rust, Benjamin Strobel, Stefan G. Kauschke, Bar Makovoz, Heike Neubauer, Remko A. Bakker, Timothy A. Blenkinsop. Frontiers in Cell and Developmental Biology