Tingting Jiang, PhD
About Me
Dr. Jiang is an Assistant Professor with the Icahn Genomics Institute and the Department of Oncological Sciences. Her research is focused on the development of CRISPR-based technology for the study and treatment of human genetic diseases. One of the major focuses of her research is the development of advanced CRISPR-associated gene editing tools, such as base editors and prime editors, to treat the inherited lung disease, Cystic Fibrosis. She has pioneered new approaches to correct CF mutations. Her long-term goal is to apply these strategies to animal models and patient samples, aiding the development of personalized gene therapy and boosting existing therapies for cystic fibrosis patients. In addition to her work on CF, Dr. Jiang will also lead the programs to expand the application scopes of CRISPR-based genome editing in studying extrachromosomal DNA mutations (such as mitochondrial DNA) and modulating liver cancer drug resistance.
Dr. Jiang did her PhD in the lab of Dr. Boon Chuan Low at the National University of Singapore, where she studied the spatiotemporal regulation of signaling networks in tumorigenesis (Oncogene, 2017). Dr. Jiang did her Postdoctoral studies at the UMass Medical School, where she developed versatile CRISPR-based techniques to study determinants of liver cancer growth and to establish approaches for genetic disease correction. Utilizing CRISPR screens, she identified a potential drug target for hepatocellular carcinoma (HCC) and discovered crosstalk mechanisms involving mitochondrial function and de novo nucleotide synthesis that influenced liver cancer cell growth (Hepatology, 2021). In parallel, Dr. Jiang developed several novel technologies to improve CRISPR therapeutics (Hum Gene Ther, 2018; Nat Biomed Eng, 2020), including creating a new version of prime editor to rewrite long genomic sequence (Nat Biotechnol, 2021) and establishing an efficient base editing system for treatment of cystic fibrosis (Nat Comm, 2020). Dr. Jiang was awarded a highly competitive K99/R00 to further advance her research in cystic fibrosis gene therapy development.
Learn more at the Jiang Lab Website.
Language
Position
Research Topics
Biomedical Sciences, Cancer, Cancer Genetics, Cell Biology, DNA Recombination, DNA Repair, Gene Expressions, Gene Therapy, Gene editing, Genetics, Genomics, Liver, Lung, Mitochondria, Molecular Biology
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Genetics and Genomic Sciences [GGS]
About Me
Dr. Jiang is an Assistant Professor with the Icahn Genomics Institute and the Department of Oncological Sciences. Her research is focused on the development of CRISPR-based technology for the study and treatment of human genetic diseases. One of the major focuses of her research is the development of advanced CRISPR-associated gene editing tools, such as base editors and prime editors, to treat the inherited lung disease, Cystic Fibrosis. She has pioneered new approaches to correct CF mutations. Her long-term goal is to apply these strategies to animal models and patient samples, aiding the development of personalized gene therapy and boosting existing therapies for cystic fibrosis patients. In addition to her work on CF, Dr. Jiang will also lead the programs to expand the application scopes of CRISPR-based genome editing in studying extrachromosomal DNA mutations (such as mitochondrial DNA) and modulating liver cancer drug resistance.
Dr. Jiang did her PhD in the lab of Dr. Boon Chuan Low at the National University of Singapore, where she studied the spatiotemporal regulation of signaling networks in tumorigenesis (Oncogene, 2017). Dr. Jiang did her Postdoctoral studies at the UMass Medical School, where she developed versatile CRISPR-based techniques to study determinants of liver cancer growth and to establish approaches for genetic disease correction. Utilizing CRISPR screens, she identified a potential drug target for hepatocellular carcinoma (HCC) and discovered crosstalk mechanisms involving mitochondrial function and de novo nucleotide synthesis that influenced liver cancer cell growth (Hepatology, 2021). In parallel, Dr. Jiang developed several novel technologies to improve CRISPR therapeutics (Hum Gene Ther, 2018; Nat Biomed Eng, 2020), including creating a new version of prime editor to rewrite long genomic sequence (Nat Biotechnol, 2021) and establishing an efficient base editing system for treatment of cystic fibrosis (Nat Comm, 2020). Dr. Jiang was awarded a highly competitive K99/R00 to further advance her research in cystic fibrosis gene therapy development.
Learn more at the Jiang Lab Website.
Language
Position
Research Topics
Biomedical Sciences, Cancer, Cancer Genetics, Cell Biology, DNA Recombination, DNA Repair, Gene Expressions, Gene Therapy, Gene editing, Genetics, Genomics, Liver, Lung, Mitochondria, Molecular Biology
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Genetics and Genomic Sciences [GGS]