Publications:32
Tristan Shuman, PhD
About Me
Tristan Shuman is an Assistant Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. His research focuses on how the brain produces precise neural activity to perform memory tasks and how these processes break down in models of disease such as epilepsy and Alzheimer's disease. His lab uses in vivo calcium imaging with miniature microscopes as well as electrophysiology to investigate the network alterations that produce cognitive deficits and seizures in mouse models of disease. Dr. Shuman obtained his PhD in Experimental Psychology from University of California, San Diego, where he examined how addiction-related memory ensembles contributed to cocaine drug seeking. Prior to joining the faculty at Mount Sinai, Dr. Shuman was a postdoctoral fellow at the University of California, Los Angeles where he examined network alterations in epileptic mice.
Language
English
Position
ASSOCIATE PROFESSOR | Neuroscience, ASSOCIATE PROFESSOR | Graduate Education
Research Topics
Alzheimer's Disease, Autism, Computational Neuroscience, Electrophysiology, Epilepsy, Extracellular Unit Recording, Hippocampus, Memory, Neuroscience, Seizure, Stem Cells, Systems Neuroscience, Transplantation
Multi-Disciplinary Training Areas
Neuroscience [NEU]
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PhD, University of California, San Diego
, University of California, Los Angeles
Awards
2020
Shah Research Scholar
Friedman Brain Institute
2018
CURE Taking Flight Award
CURE Epilepsy
2018
AES Junior Investigator Award
American Epilepsy Society
2018
Nash Family Scholar
Friedman Brain Institute
2016
AES Young Investigator Award
American Epilepsy Society
2015
AES Grass Young Investigator Award
American Epilepsy Society
2014
Epilepsy Foundation Postdoctoral Fellowship
Epilepsy Foundation
Research
Epilepsy is a debilitating disorder that affects over 3 million Americans, with 30% of patients unresponsive to anti-epileptic drugs and often resorting to large resections of the brain. Therefore, it is critical to develop new therapeutic interventions to suppress seizures and cognitive deficits in epilepsy. My lab uses state of the art recording and manipulation techniques to examine how abnormal circuit processing leads to seizures and cognitive deficits in epilepsy and to understand how seizures and cognitive deficits can be suppressed with novel interventions. We use in vivo calcium imaging with miniature microscopes as well as in vivo electrophysiology with silicon probes to examine how the epileptic brain is altered in mice.
Publications
Selected Publications
- A comprehensive suite for extracting neuron signals across multiple sessions in one-photon calcium imaging. Pablo Vergara, Yuteng Wang, Sakthivel Srinivasan, Zhe Dong, Yu Feng, Iyo Koyanagi, Deependra Kumar, Yoan Chérasse, Toshie Naoi, Yuki Sugaya, Takeshi Sakurai, Masanobu Kano, Tristan Shuman, Denise Cai, Masashi Yanagisawa, Masanori Sakaguchi. Nature Communications
- Simultaneous two-color imaging with a dual-channel miniscope in freely behaving mice. Zhe Dong, Yu Feng, Keziah Diego, Austin M. Baggetta, Brian M. Sweis, Zachary T. Pennington, Sophia I. Lamsifer, Yosif Zaki, Federico Sangiuliano, Paul A. Philipsberg, Denisse Morales-Rodriguez, Daniel Kircher, Paul Slesinger, Tristan Shuman, Daniel Aharoni, Denise J. Cai. Science advances
- Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy. Yu Feng, Keziah S. Diego, Zhe Dong, Zoé Christenson Wick, Lucia Page-Harley, Veronica Page-Harley, Julia Schnipper, Sophia I. Lamsifer, Zachary T. Pennington, Lauren M. Vetere, Paul A. Philipsberg, Ivan Soler, Albert Jurkowski, Christin J. Rosado, Nadia N. Khan, Denise J. Cai, Tristan Shuman. Cell Reports
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Shuman has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.