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Viviana A Simon, MD, PhD
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About Me
Dr. Simon studies emerging pathogens. She has been awarded several grants from the National Institutes of Health for her investigations of HIV and has received several honors and awards for her work.
Video
Watch a video featuring the Microbiology and Virology PhD Graduate School Program.
Language
Position
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Microbiology [MIC]
About Me
Dr. Simon studies emerging pathogens. She has been awarded several grants from the National Institutes of Health for her investigations of HIV and has received several honors and awards for her work.
Video
Watch a video featuring the Microbiology and Virology PhD Graduate School Program.
Language
Position
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Microbiology [MIC]
About Me
Dr. Simon studies emerging pathogens. She has been awarded several grants from the National Institutes of Health for her investigations of HIV and has received several honors and awards for her work.
Video
Watch a video featuring the Microbiology and Virology PhD Graduate School Program.
Language
Position
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Microbiology [MIC]
Education
Residency, Auguste Viktoria Hospital
, The Rockefeller University
, The Rockefeller University
MD, Humboldt University
PhD, University of Rostock
Awards
2008
Sinsheimer Scholar (Alexandrine and Alexander L. Sinsheimer Fund)
Research
Specific Clinical/Research Interest:
HIV pathogenesis and host-virus interactions
Current Students: Mawuena Binka, Susan Majdak
Postdoctoral Fellows: Marcel Ooms
Research Personnel: Ariana Harari
Summary of Research Studies:
My research focuses on HIV-1 pathogenesis and viral host interactions. Complex organisms evolved both innate and adaptive immune defenses to prevent viral infection and/or dissemination. Recently,it became apparent that a group of constitutively expressed genes can efficiently restrict replication of endogenous and exogenous viruses in a species specific manner. Host cells use DNA/RNA editing enzymes as ways to curb invasion from viruses. For example, human APOBEC3G (APOlipoprotein B Editing Complex 3G) has been shown to be active against exogenous retroviruses (HIV-1, HIV-2, Foamy), endogenous mobile genetic elements (e.g., LTR retrotransposons) and DNA viruses (e.g., Hepatitis B). One of the mode of action of cytidine deaminases is one of extensive mutagenesis. The HIV-1 gene Vif effectively counters the antiretroviral activity of APOBEC3G by inducing its degradation. The nucleotide composition of the HIV-1 genome suggests, however, that protection from host-mediated viral cDNA deamination may not be absolute. We have shown that Vif alleles that fail to degrade APOBEC3G, APOBEC3F or both can be detected in vivo. We speculate that intrinsic restriction mediated by cytidine deaminases contributes to HIV-1 sequence diversification.
Locations
Publications
Selected Publications
- Corrigendum to “Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study” [eBioMedicine 83 (2022) 104208] (eBioMedicine (2022) 83, (S2352396422003905), (10.1016/j.ebiom.2022.104208)). Al Ozonoff, Joanna Schaenman, Naresh Doni Jayavelu, Carly E. Milliren, Carolyn S. Calfee, Charles B. Cairns, Monica Kraft, Lindsey R. Baden, Albert C. Shaw, Florian Krammer, Harm van Bakel, Denise A. Esserman, Shanshan Liu, Ana Fernandez Sesma, Viviana Simon, David A. Hafler, Ruth R. Montgomery, Steven H. Kleinstein, Ofer Levy, Chris Bime, Elias K. Haddad, David J. Erle, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Catherine L. Hough, William B. Messer, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Mark A. Atkinson, Scott C. Brakenridge, David Corry, Farrah Kheradmand, Lauren I.R. Ehrlich, Esther Melamed, Grace A. McComsey, Rafick Sekaly, Joann Diray-Arce, Bjoern Peters, Alison D. Augustine, Elaine F. Reed, Matthew C. Altman, Patrice M. Becker, Nadine Rouphael. eBioMedicine
- Sequential intrahost evolution and onward transmission of SARS-CoV-2 variants. Ana S. Gonzalez-Reiche, Gopi Patel, Nima Assad, Bremy Alburquerque, Giulio Kleiner, Lubbertus C.F. Mulder, Robert Sebra, Florian Krammer, Emilia Mia Sordillo, Viviana Simon, Harm van Bakel. Nature Communications
- Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study. Hallie Cohn, Nathaniel Bloom, Gianna Y. Cai, Jordan J. Clark, Alison Tarke, Maria C. Bermúdez-González, Deena R. Altman, Luz Amarilis Lugo, Francisco Pereira Lobo, Susanna Marquez, Angela Amoako, Dalles Andre, Harm van Bakel, Christian C. Cognini, Charles Gleason, Ana Gonzales-Reiche, Morgan van Kesteren, Giulio Kleiner, Neko Lyttle, Jacob D. Mauldin, Brian C. Monahan, Jessica R. Nardulli, Annika Oostenink, Alberto Paniz-Mondolfi, Jose Polanco, Juan David Ramírez, Aria Rooker, Emilia Mia Sordillo, Komal Srivastava, Jin Qiu Chen, Wenlin Ren, Lili Qin, Jennifer L. Yates, Danielle T. Hunt, William T. Lee, Shane Crotty, Florian Krammer, Alba Grifoni, Alessandro Sette, Viviana Simon, Camila H. Coelho. The Lancet Infectious Diseases