Wenyan Jiang, PhD

Wenyan Jiang, PhD, is an Assistant Professor of Genetics and Genomic Sciences and Microbiology. He is also a faculty member of the Icahn Genomics Institute (IGI) and the Marc and Jennifer Lipshultz Precision Immunology Institute (PrIISM).

Dr. Jiang builds technologies to fuel new discovery in the microbial world. Over the last decade, he has developed revolutionary technologies that enhance the precision, throughput and resolution for bacterial genomics and transcriptomics. These include development of the very first CRISPR-Cas9 genome editing (Nature Biotech 2013, >2000 citations) and transcriptional modulation technology (Nucleic Acids Research 2013, >1000 citations) in bacteria; a high-throughput bacterial functional genomics platform, CALM (Cell 2020); and the first bacterial high-throughput single-cell RNA sequencing technology, PETRI-seq (Nature Microbiol 2020).

Adopted by many labs around the world, these technologies have substantially expanded scientists’ ability to solve fundamental and applied questions in complex microbial systems. By applying them to clinically and industrially important non-model microbes that are traditionally hard to manipulate, the Jiang Lab aims to study microbiology at a systems-level, such as understanding genetic interaction networks, evolution, single-cell behaviors, microbe-phage, and host-microbe interactions. The fundamental principles we learn from these studies could then help us develop more effective antimicrobial drugs, and engineer commensal bacteria to promote human health.

Learn more at: jianglab.org