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Profile image of Xiang Xu

    Xiang Xu, PhD

    Education

    B Eng, Jilin University

    PhD, New York University

    Postdoctoral fellowship, The Johns Hopkins University School of Medicine

    Awards

    2021

    Mount Sinai Distinguished Scholar Award

    Icahn School of Medicine at Mount Sinai

    2017

    magna cum laude

    International Society for Magnetic Resonance in Medicine

    2015

    Golden Hairball Award

    Johns Hopkins University School of Medicine, Department of Radiology

    2013

    summa cum laude

    International Society for Magnetic Resonance in Medicine

    Research

    Current clinical MRI contrast agents contain paramagnetic Gadolinium which are not safe for patients with compromised kidney function and a most recent study has shown that these agents leave permanent residues in brain tissues even in people with normal renal function. There is an urgent need in finding new, biocompatible contrast agents. I was one of the first to develop the use of D-glucose as a contrast agent for MRI. Glucose is the simplest form of sugar in our everyday life and it is the fuel for all cell activities. Through careful design and optimization, I was able to create an MRI experiment to dynamically monitor the uptake of glucose. When injecting glucose into mice implanted with a human brain tumor, I observed very good signal enhancements in the tumor region. In addition, the dynamic experiment I designed also provides information regarding how fast glucose is taken up by the tumor therefore reflecting the integrity of the blood brain barrier around the tumor. I am interested in exploiting the physiological origin of glucose contrast enhancement and developing imaging techniques that are sensitive to glucose.