Publications:29
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Yuko Hara, PhD
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About Me
I obtained my Ph.D. in Neurology and Neuroscience at the Weill Cornell Graduate School, NY, NY. As a Postdoctoral Fellow in Dr. John Morrison's laboratory, I examined the synaptic and molecular signatures of aging and recognition memory decline in the hippocampus of cognitively-assessed animals.
Language
Position
Research Topics
Aging, Cognitive Neuroscience, Glutamate (NMDA & AMPA) Receptors, Hippocampus, Memory, Mitochondria, Neurobiology, Neuroscience, Prefrontal Cortex, Synapses
About Me
I obtained my Ph.D. in Neurology and Neuroscience at the Weill Cornell Graduate School, NY, NY. As a Postdoctoral Fellow in Dr. John Morrison's laboratory, I examined the synaptic and molecular signatures of aging and recognition memory decline in the hippocampus of cognitively-assessed animals.
Language
Position
Research Topics
Aging, Cognitive Neuroscience, Glutamate (NMDA & AMPA) Receptors, Hippocampus, Memory, Mitochondria, Neurobiology, Neuroscience, Prefrontal Cortex, Synapses
About Me
I obtained my Ph.D. in Neurology and Neuroscience at the Weill Cornell Graduate School, NY, NY. As a Postdoctoral Fellow in Dr. John Morrison's laboratory, I examined the synaptic and molecular signatures of aging and recognition memory decline in the hippocampus of cognitively-assessed animals.
Language
Position
Research Topics
Aging, Cognitive Neuroscience, Glutamate (NMDA & AMPA) Receptors, Hippocampus, Memory, Mitochondria, Neurobiology, Neuroscience, Prefrontal Cortex, Synapses
Education
BS, Cornell University
PhD, Weill Cornell Graduate School of Medical Sciences
Awards
2010
Ellison Medical Foundation/American Federation for Aging Research (AFAR)
2005
Supreme Council of Freemason's Scottish Rite Fellowship
Research
We are interested in identifying the neurobiological basis of age- and menopause-related cognitive decline. We utilize electron microscopic techniques to examine synaptic and mitochondrial ultrastructure as well as molecular profiles in key brain areas mediating cognitive functions. We are also interested in the effects of estrogen on the brain and the ways in which it can restore cognitive and synaptic functions in aged menopausal animals. Results from our research have important implications for treating age- and menopause-related cognitive symptoms in humans.
Locations
Publications
Selected Publications
- Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline. Johanna L. Crimins, Rishi Puri, Katina C. Calakos, Frank Yuk, William G.M. Janssen, Yuko Hara, Peter R. Rapp, John H. Morrison. Journal of Comparative Neurology
- Estrogen Alters the Synaptic Distribution of Phospho-GluN2B in the Dorsolateral Prefrontal Cortex While Promoting Working Memory in Aged Rhesus Monkeys. Yuko Hara, Johanna L. Crimins, Rishi Puri, Athena C.J. Wang, Sarah E. Motley, Frank Yuk, Tiffany M. Ramos, William G.M. Janssen, Peter R. Rapp, John H. Morrison. Neuroscience
- Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. Sam Horng, Anthony Therattil, Sarah Moyon, Alexandra Gordon, Karla Kim, Azeb Tadesse Argaw, Yuko Hara, John N. Mariani, Setsu Sawai, Per Flodby, Edward D. Crandall, Zea Borok, Michael V. Sofroniew, Candice Chapouly, Gareth R. John. Journal of Clinical Investigation
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Hara did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.