Publications:19
Yuko Hara, PhD
About Me
I obtained my Ph.D. in Neurology and Neuroscience at the Weill Cornell Graduate School, NY, NY. As a Postdoctoral Fellow in Dr. John Morrison's laboratory, I examined the synaptic and molecular signatures of aging and recognition memory decline in the hippocampus of cognitively-assessed animals.
Language
English
Position
ADJUNCT ASSISTANT PROFESSOR | Neuroscience
Research Topics
Aging, Cognitive Neuroscience, Glutamate (NMDA & AMPA) Receptors, Hippocampus, Memory, Mitochondria, Neurobiology, Neuroscience, Prefrontal Cortex, Synapses
Education
BS, Cornell University
PhD, Weill Cornell Graduate School of Medical Sciences
Awards
2010
Ellison Medical Foundation/American Federation for Aging Research (AFAR)
2005
Supreme Council of Freemason's Scottish Rite Fellowship
Research
We are interested in identifying the neurobiological basis of age- and menopause-related cognitive decline. We utilize electron microscopic techniques to examine synaptic and mitochondrial ultrastructure as well as molecular profiles in key brain areas mediating cognitive functions. We are also interested in the effects of estrogen on the brain and the ways in which it can restore cognitive and synaptic functions in aged menopausal animals. Results from our research have important implications for treating age- and menopause-related cognitive symptoms in humans.
Publications
Selected Publications
- Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline. Johanna L. Crimins, Rishi Puri, Katina C. Calakos, Frank Yuk, William G.M. Janssen, Yuko Hara, Peter R. Rapp, John H. Morrison. Journal of Comparative Neurology
- Estrogen Alters the Synaptic Distribution of Phospho-GluN2B in the Dorsolateral Prefrontal Cortex While Promoting Working Memory in Aged Rhesus Monkeys. Yuko Hara, Johanna L. Crimins, Rishi Puri, Athena C.J. Wang, Sarah E. Motley, Frank Yuk, Tiffany M. Ramos, William G.M. Janssen, Peter R. Rapp, John H. Morrison. Neuroscience
- Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. Sam Horng, Anthony Therattil, Sarah Moyon, Alexandra Gordon, Karla Kim, Azeb Tadesse Argaw, Yuko Hara, John N. Mariani, Setsu Sawai, Per Flodby, Edward D. Crandall, Zea Borok, Michael V. Sofroniew, Candice Chapouly, Gareth R. John. Journal of Clinical Investigation