Yuxin Liu, MD, PhD

Dr. Yuxin Liu is a Professor of Pathology in the Division of Gynecologic Pathology. She has a strong academic interest in the field of HPV-associated anal cancer and cervical cancer. Together with Drs. Michael Gaisa and Keith Sigel in the Department of Medicine, they lead a productive and translational anal cancer research program within the Mount Sinai Health System (PPAC). Dr. Liu is co-PI for three NCI-funded clinical trials, including the first trial of anal cancer screening among HIV-negative women at risk (SWAN study).

Dr. Liu has served as the Board of Directors of the International Anal Neoplasia Society (IANS) 2021-2023, an organization dedicated to anal cancer prevention and treatment. Currently, Dr. Liu is the Director of the AIDS Malignancy Consortium (AMC) HPV Core Laboratory and performs central pathology review for multiple AMC clinical trials conducted nationally and internationally.

IANS pathology website: https://www.iansoc.org/Pathology

SWAN study: https://www.swan-study.org/

PPAC: https://www.mountsinai.org/patient-care/iam/services/anal-cancer-prevention-program

Publications:

1. Stier EA, Clarke MA, Deshmukh AA, Wentzensen N, Liu Y, Poynten IM, Cavallari EN, Fink V, Barroso LF, Clifford GM, Cuming T, Goldstone SE, Hillman RJ, Rosa-Cunha I, La Rosa L, Palefsky JM, Plotzker R, Roberts JM, Jay N. International Anal Neoplasia Society's consensus guidelines for anal cancer screening. Int J Cancer. 2024 Jan 31. PMID: 38297406.

2. Yuxin Liu, Bhardwaj S, Sigel K, Winters J, Terlizzi J, Gaisa MM. Anal cancer screening results from 18-to-34-year-old men who have sex with men living with HIV. Int J Cancer. 2024 Jan 1;154(1):21-27. PMID: 37728489.     

3. Yuxin Liu, Kevin Weiss, Andrés Ramírez Zamudio, Monica Prasad Hayes, Mona Saleh, Michael M Gaisa, Keith Sigel. Primary Anal Cancer Screening Results from 381 Women Living with HIV. J Infect Dis. 2023;227(8):932-938. PMID: 36196502.     

4. Yuxin Liu, W Glenn McCluggage, Teresa M Darragh, et al. p16 Immunoreactivity Correlates with Morphological Diagnosis of HPV-associated Anal Intraepithelial Neoplasia: A study of 1,000 Biopsies. Am J Surg Pathol. 2021;45(11):1573-1578. PMID: 34231547     

5. Michael M Gaisa, Keith M Sigel, Ashish A Deshmukh, Volha Lenskaya, Courtney A Chan, Richard Silvera, John Winters, Yuxin Liu. Comparing Anal Cancer Screening Algorithms Using Cytology and HPV DNA Testing in Three High-risk Populations. J Infect Dis. 2021;224(5):881-888. PMID: 33388757.     

6. Yuxin Liu, Monica Prasad Hayes, Eric M. Ganz, Juan Lucas Poggio, Volha Lenskaya, Threshia Malcolm, Ashish Deshmukh, Wenxin Zheng, Keith Sigel and Michael M. Gaisa. HIV-Positive Women with Anal HSIL: A study of 153 Cases with Long-Term Anogenital Surveillance. Modern Pathology 2020;33(8):1589-1594. PMID: 32152521     

7. Yuxin Liu, W Glenn McCluggage, Teresa M. Darragh, Wenxin Zheng, Jennifer M. Roberts, Kay J. Park, Pei Hui, Morgan Blakely, Keith Sigel, Michael M. Gaisa. Classifying AIN 2 Based on LAST Recommendations: Interobserver Agreement Among Experienced Pathologists. Am J Clin Pathol. 2021;18;155(6):845-852. PMID: 33210115     

8. Michael Gaisa, Yuxin Liu, Ashish A. Deshmukh, Kimberly Stone, Keith Sigel. Electrocautery Ablation of Anal High-grade Squamous Intraepithelial Lesions: Effectiveness and Key Factors Associated with Outcomes. Cancer. 2020;126(7):1470-1479. PMID: 31977082     

9. Yuxin Liu, Keith M Sigel, William Westra, Melissa R Gitman, Wenxin Zheng, Michael M Gaisa. HIV-infected Patients with Anal Cancer Precursors: Clinicopathological Characteristics and HPV Subtype Distribution. Dis Colon Rectum 2020;63(7):890-896. PMID: 32168092     

10. Ashish A Deshmukh, Ryan Suk, Meredith S Shiels, Kalyani Sonawane, Alan G Nyitray, Yuxin Liu, Michael M Gaisa, Joel M Palefsky, Keith Sigel. Recent trends in squamous cell carcinoma of the anus incidence and mortality in the United States, 2001-2015. J Natl Cancer Inst. 2020;112(8):829-838. PMID: 31742639